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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The chronic toxicity of N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine (6PPD) to fish was tested with Oryzias latipes in a Early-Life Stage Toxicity Test according to OECD Guideline 210. The 30d NOEC is 0.0037 mg/L. ( National Institute of Technology and Evaluation, Japan, 2003)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.004 mg/L

Additional information

No long-term toxicity study to fish for 77PD is available. 6PPD is an analogues substance. Due to the analogous structure of 6PPD, this study is used in a read-across approach for 77PD. A detailed justification for the read-across is given in a separate document attached to IUCLID chapter 13.

A chronic fish test according to OECD 210 is available for tyre wear particles (Marwood 2010).TWPs are produced containing antioxidants like 7PPD in a concentration of about 1%. Pimephales promelas showed no biological significant effect in a 32-day study concerning hatching success, survival and growth.