Registration Dossier

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Although the Fujiwara study indicates a NOAEC below 10 ppm, the results generated are of limited value only. The study was not performed to any standard protocol with experimental procedures carried out to a low standard.

Key value for chemical safety assessment

Additional information

Many details concerning the experimental set-up are lacking and there was no analytical monitoring performed. The latter is important as it can not be excluded that the water contained an unrealistic high concentration of TDA, depending on the mode of "stirring" of TDI into the water.

The chronic toxicity of the TDI hydrolysis product, TDA, was established in an OECD 212 study (III ref 11453) with an LOAEC of 10 mg/L (behaviour: odd swimming) and a NOAEC of 3.16 mg/l. The results of Yakabe et al, 1999 (see section 5.1.2 Hydrolysis) indicate that the hydrolysis of 10mg TDI/l may lead to the formation of about 4mg TDA/l. Therefore, the findings with TDI may be attributable to TDA. However, water is a carefully avoided reactant to TDI and is carefully controlled in all processes of TDI production and use. Vigorous stirring of TDI into water has no practical relevance. As a result of this and due to the poor quality of the chronic fish study, the value generated for the chronic fish toxicity of TDI should not be used for the Chemical Safety Assessment.