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EC number: 209-544-5 | CAS number: 584-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- data not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to guideline study. No GLP. TDI isomer ratio is specified but the purity is not stated.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicology and Carcinogenesis studies of commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5) in F344/N rats and B6C3F1 mice (gavage studies)
- Author:
- National Toxicology Program
- Year:
- 1 986
- Bibliographic source:
- NTP TR 251, NIH Publication No. 86-2507, US Dept. of Health and Human Services, NC, USA
- Reference Type:
- publication
- Title:
- Toxicology, industrial hygiene and medical control of TDI, MDI and PMPPI
- Author:
- Woolrich PF
- Year:
- 1 982
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 43 (2): 89-97
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- m-tolylidene diisocyanate
- EC Number:
- 247-722-4
- EC Name:
- m-tolylidene diisocyanate
- Cas Number:
- 26471-62-5
- Molecular formula:
- C9 H6 N2 O2
- IUPAC Name:
- m-tolylidene diisocyanate
- Details on test material:
- - Name of test material (as cited in study report title): commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Frederick Cancer Research Center (Frederick MD)
- Age at study initiation: approximately 10 weeks old
- Weight at study initiation: 144-163 g for female; 222-272 g for male
- Fasting period before study: no data
- Housing: two or three per cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: approximately 6 weeks
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 500 mg/ml
- Amount of vehicle (if gavage): data not available
- Justification for choice of vehicle: data not available.
MAXIMUM DOSE VOLUME APPLIED: data not available
- Doses:
- 2150, 3160, 4640, 6810, 10000, 14700 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations (1) and weighing (2):
(1) Observations for mortality: they were made every 30 minutes for the first 8 hours and then daily for the rest of the study,
(2) Weighing: on test day 1 (prior to administration) and on day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs. - Statistics:
- no statistical analysis was used
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 110 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 130 mg/kg bw
- Mortality:
- Yes. Mortality was proportional to the dose of substance administered. For more details see Table 1 in the text field "remarks on results including tables and figures".
- Clinical signs:
- other: At 10,000 or 14,700 mg/kg death was preceded by laboured breathing, inactivity and diarrhea.
- Gross pathology:
- No macroscopic findings were reported.
- Other findings:
- White crystals in stomach and dark red lungs were found at necropsy, findings were dose related.
Any other information on results incl. tables
Table 1: Number of animals dead and time range within which mortality occured
Dose (mg/kg bw) |
Mortality (# dead/total) | Time range of deaths (days) | ||
Male | Female | Combined | ||
2150 | 2/5 | 0/5 | 2/10 | (5-9) |
3160 | 3/5 | 2/5 | 5/10 | (1-14) |
4640 | 2/5 | 2/5 | 4/10 | (2-10) |
6810 | 2/5 | 5/5 | 7/10 | (2-5) |
10000 | 5/5 | 4/5 | 9/10 | (1-3) |
14700 | 5/5 | 5/5 | 10/10 | (1-2) |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- The commercial grade 2,4 (80 %)-and 2,6 (20 %)-TDI was not considered to be toxic by this route. This test substance is not classified according to EU criteria and the EU-GHS.
- Executive summary:
In an acute oral toxicity study (NTP, 1986), groups of 10 weeks old F344/N rats (5/sex) were given a single oral dose of commercial grade toluene diisocyanate (80% 2,4- and 20% 2,6 -) in corn oil by gavage at doses of 2150, 3160, 4640, 6810, 10000, 14700 mg/kg bw and observed for 14 days. Mortality was proportional to the dose of substance administered. Loss in mean body weight was greater than 10 g in all groups of dosed males. In rats receiving 10,000 or 14,700 mg/kg death was preceded by labored breathing, inactivity, and diarrhea. White, crystalline material was found in the stomach and dark red lungs were observed at necropsy: these findings were dose related. Under the conditions of this test, the acute oral LD50 is > 2,000 mg/kg.
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