Registration Dossier
Registration Dossier
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EC number: 201-149-6 | CAS number: 78-84-2
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment report for SIAM 5: Isobutanal CAS No: 78-84-2
- Author:
- OECD SIDS
- Year:
- 2 004
Materials and methods
- Type of study / information:
- Effects after exposure of male volunteers
- Endpoint addressed:
- respiratory irritation
- Principles of method if other than guideline:
- 15 male volunteers exposed to 210 ppm vapour for 30 min
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isobutyraldehyde
- EC Number:
- 201-149-6
- EC Name:
- Isobutyraldehyde
- Cas Number:
- 78-84-2
- Molecular formula:
- C4H8O
- IUPAC Name:
- 2-methylpropanal
- Details on test material:
- - Name of test material: Isobutanal
Constituent 1
Method
- Ethical approval:
- not specified
- Exposure assessment:
- not specified
- Details on exposure:
- 15 male volunteers were exposed to 210 ppm (620 mg/m3) isobutanal vapour for 30 min
Results and discussion
- Results:
- No irritation was observed. Nausea was noted by some of the subjects, and one subject vomited.
Applicant's summary and conclusion
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