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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

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Description of key information

Key value for chemical safety assessment

Additional information

Studies on the rate of uptake of isobutanal through the intact skin are not available; dermal uptake through the vulnerated skin after prolonged exposure and occlusive conditions has been shown in the course of an old acute dermal toxicity study. (Union Carbide, 1952; cited in OECD SIDS 2004)

Isobutanal, like other simple aliphatic aldehydes, is subject to oxidation in animals by ubiquitous aldehyde dehydrogenase enzymes. The oxidation product, isobutyric acid, is rapidly metabolized to CO2 through conversion to the isobutyral coenzyme A complex and subsequent oxidation by the malate-pyruvate and oxaloacetic-phosphoenol pyruvate pathways (DiVincenzo and Hamilton, 1979; cited in OECD SIDS 2004).

In in vitro studies, isobutyraldehyde was shown to undergo oxidative deformylation catalyzed by rabbit liver cytochrome P450 enzymes yielding propylene and formic acid (Roberts et al., 1991, Proc. Natl. Acad. Sci. 88, 8963 - 8966); cited in NTP TR 472, 1999). Isobutyraldehyde showed little oxidation by rat liver mitochondria (Smith and Packer, 1972, Arch.Biochem.Biophys. 148.270 -276; cited in NTP TR 472, 1999).