Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Isobutyraldehyde did not cause ear swelling or cell proliferation in a combined MEST and radioisotopic assay.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

NTP 1990 reported a study, where isobutyraldehyde was tested on female B6C3F1 mice. The doses of isobutyraldehyde ranged from 3% to 30% in a solution of 4 parts acetone to one part olive oil (4:1) for induction and 30% for challenge. Mice received 20 µL by direct dermal application for 5 consecutive days to a shaved and dermabraded site. DNFB (1-fluoro-2,4-dinitrobenzene) (98%) was used as a positive control at a concentration of 0.5%. Measurement of the contact hypersensitivity was accomplished by the radioisotopic assay and the mouse ear swelling test (MEST). No statistically significant dose-dependent contact hypersensitivity response to isobutyraldehyde was demonstrated in mice with or without adjuvant.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available information classification for skin sensitisation is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.