Trichloroethylene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Studies with regard to acute oral toxicity, acceptable for assessment, also peer-reviewed under Regulation 793/93.

Data source

Reference

Reference Type:

other: EU Risk Assessment Report (RAR)

Title:

Trichloroethylene

Author:

Rapporteur: United Kingdom, on behalf of the European Union

Year:

2004

Materials and methods

Test type:

other:

Test material

Test material information

Constituent 1

Reference substance name:

Trichloroethylene

EC Number:

201-167-4

EC Name:

Trichloroethylene

Cas Number:

79-01-6

Molecular formula:

C2HCl3

IUPAC Name:

1,1,2-trichloroethene

Constituent 2

Reference substance name:

trichloroethene

IUPAC Name:

trichloroethene

Test animals

Species:

other: guinea pig, rabbit

Strain:

not specified

Administration / exposure

Type of coverage:

other: occlusive & semiocclusive

Vehicle:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 20 000

Based on:

other: rabbit

Applicant's summary and conclusion

Conclusions:

The LD50 value of trichloroethylene in rabbits when administered by the dermal route, using an occlusive dressing, has been reported as being greater than 29000 mg/kg body weight .
In another study, the LD50 value in the rabbit following a 24-hour exposure with a semi-occlusive dressing was reported to be > 20000 mg/kg.
No deaths occurred in guinea-pigs following dermal
application of 7800 mg/kg body weight of trichloroethylene using a similar method: the only sign of toxicity noted was reduced weight gain during the 35-day post-exposure observation period.