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EC number: 201-167-4
CAS number: 79-01-6
is not possible to draw any firm conclusions about the reproductive
toxicity of trichloroethylene on the basis of the available human data.
oral (diet) continuous breeding studies are available, one in rats and
one in mice. In the rat study, trichloroethylene produced general
toxicity (reduced body weight gain, increased relative liver and kidney
weights) at all doses (75, 150 and 300 mg/kg bw/day), while reducing
reproductive indices only at the middle and high dose levels. Thus,
trichloroethylene was not found to be a selective reproductive toxicant
A guideline-compliant developmental study with rats showed no developmental effects at any exposure level tested. Maternal effects were observed at the highest tested concentration (600 ppm), so the NOAEL is 150 ppm.