Registration Dossier
Registration Dossier
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EC number: 211-708-6 | CAS number: 688-84-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Occupational allergic contact dermatitis caused by exposure to acrylates during work with dental prostheses
- Author:
- Kanerva L, Estlander T, Jolanki R, Tarvainen K
- Year:
- 1 993
- Bibliographic source:
- Contact. Derm. 28: 268-275
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 3 patients (24-32 years old) with allergic occupational contact dermatitis caused by exposure to acrylates during work with dental protheses were patch tested with 2-ethylhexyl methacrylate (1% in petrolatum)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexyl methacrylate
- EC Number:
- 211-708-6
- EC Name:
- 2-ethylhexyl methacrylate
- Cas Number:
- 688-84-6
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 2-ethylhexyl methacrylate
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 4
- Sex: female
- Age: 23-32 years
- Race: no data
- Demographic information: no data - Clinical history:
- - History of allergy or casuistics for study subject or populations: occupational contact dermatitis
- Symptoms, onset and progress of the disease: fingertips, hands or face
- Exposure history: 1.5-2 years - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: semi-occlusive for 24h
- Description of patch: Finn chamber
- Vehicle / solvent: petrolatum
- Concentrations: 1%
- Volume applied: no data
- Testing/scoring schedule: on removal and 24, 48, and 96-120 h after removal
- Removal of test substance: no data
EXAMINATIONS
- Grading/Scoring system: recommendations of the Finnish contact dermatitis group
- Statistical analysis: no data
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed: none
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0
Applicant's summary and conclusion
- Conclusions:
- No patients showed positive allergic skin reactions.
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