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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Occupational allergic contact dermatitis caused by exposure to acrylates during work with dental prostheses
Author:
Kanerva L, Estlander T, Jolanki R, Tarvainen K
Year:
1993
Bibliographic source:
Contact. Derm. 28: 268-275

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
3 patients (24-32 years old) with allergic occupational contact dermatitis caused by exposure to acrylates during work with dental protheses were patch tested with 2-ethylhexyl methacrylate (1% in petrolatum)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl methacrylate
EC Number:
211-708-6
EC Name:
2-ethylhexyl methacrylate
Cas Number:
688-84-6
Molecular formula:
C12H22O2
IUPAC Name:
2-ethylhexyl methacrylate
Test material form:
liquid

Method

Type of population:
occupational
Ethical approval:
not specified
Subjects:
- Number of subjects exposed: 4
- Sex: female
- Age: 23-32 years
- Race: no data
- Demographic information: no data
Clinical history:
- History of allergy or casuistics for study subject or populations: occupational contact dermatitis
- Symptoms, onset and progress of the disease: fingertips, hands or face
- Exposure history: 1.5-2 years
Route of administration:
dermal
Details on study design:
TYPE OF TEST(S) USED: patch test (epicutaneous test)

ADMINISTRATION
- Type of application: semi-occlusive for 24h
- Description of patch: Finn chamber
- Vehicle / solvent: petrolatum
- Concentrations: 1%
- Volume applied: no data
- Testing/scoring schedule: on removal and 24, 48, and 96-120 h after removal
- Removal of test substance: no data

EXAMINATIONS
- Grading/Scoring system: recommendations of the Finnish contact dermatitis group
- Statistical analysis: no data

Results and discussion

Results of examinations:
SYMPTOMS
- Frequency, level, duration of symptoms observed: none

NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0

Applicant's summary and conclusion

Conclusions:
No patients showed positive allergic skin reactions.