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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1970

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: not known
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl methacrylate
EC Number:
211-708-6
EC Name:
2-ethylhexyl methacrylate
Cas Number:
688-84-6
Molecular formula:
C12H22O2
IUPAC Name:
2-ethylhexyl methacrylate
Details on test material:
2-Propenoic acid, 2-methyl-, ethylhexyl ester purity not specified, but commercial grade assumed.

Test animals

Species:
rat
Strain:
other: Alderly Park
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
6 hours/day
Frequency of treatment:
5 days/week, 3 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
25, 60 ppm (= 203 and 486 mg/m³), 4 male and 4 female rats/dose
Basis:

Control animals:
other: no data specified
Details on study design:
Post-exposure period: 24 hours

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Haematological findings:
no effects observed
Urinalysis findings:
no effects observed
Gross pathological findings:
effects observed, treatment-related
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Details on results:
25 ppm: no signs of toxicity; no findings at autopsy, organs normal
60 ppm/saturated: no signs of toxicity; blood and urine tests normal;  autopsy and histology:increased cellularity in lungs.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
In a published study there were no signs of toxicity; no findings at autopsy at 25 ppm; at 60 ppm/saturated there were no signs of toxicity; blood and urine tests were normal and  autopsy and histology showed increased cellularity in lungs.
Executive summary:

No overt (clinical) signs of toxicity were observed in a screening study in which groups of eight rats (4 males and 4 females) exposed to EHMA vapour at concentrations of 60 and 25 ppm (486 and 203mg/m3) for 6 hr/day, five days per week, over 3 weeks. Gross examination of the major organs revealed no adverse effects, but microscopic examination showed some changes (increased cellularity) to the lungs of the rats exposed to the higher concentration.