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EC number: 211-708-6 | CAS number: 688-84-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not known
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl methacrylate
- EC Number:
- 211-708-6
- EC Name:
- 2-ethylhexyl methacrylate
- Cas Number:
- 688-84-6
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 2-ethylhexyl methacrylate
- Details on test material:
- 2-Propenoic acid, 2-methyl-, ethylhexyl ester purity not specified, but commercial grade assumed.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderly Park
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6 hours/day
- Frequency of treatment:
- 5 days/week, 3 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
25, 60 ppm (= 203 and 486 mg/m³), 4 male and 4 female rats/dose
Basis:
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: 24 hours
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Haematological findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Details on results:
- 25 ppm: no signs of toxicity; no findings at autopsy, organs normal
60 ppm/saturated: no signs of toxicity; blood and urine tests normal; autopsy and histology:increased cellularity in lungs.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a published study there were no signs of toxicity; no findings at autopsy at 25 ppm; at 60 ppm/saturated there were no signs of toxicity; blood and urine tests were normal and autopsy and histology showed increased cellularity in lungs.
- Executive summary:
No overt (clinical) signs of toxicity were observed in a screening study in which groups of eight rats (4 males and 4 females) exposed to EHMA vapour at concentrations of 60 and 25 ppm (486 and 203mg/m3) for 6 hr/day, five days per week, over 3 weeks. Gross examination of the major organs revealed no adverse effects, but microscopic examination showed some changes (increased cellularity) to the lungs of the rats exposed to the higher concentration.
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