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activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Meets National Standard Methods (DIN)
according to guideline
ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
GLP compliance:
Analytical monitoring:
Test organisms (species):
activated sludge, domestic
Test type:
Water media type:
Details on test conditions:
Type: aquatic
3 h
Dose descriptor:
other: EC20
Effect conc.:
> 1 000 mg/L
Nominal / measured:
Basis for effect:
inhibition of total respiration
respiration rate
DOC (calculated) 590 mg/l

30 min values:
oxygen consumption (mg02/l*h) 41,3
reference value (mg02/l*h) 39,9
delta (%) 4
EC20 (determined graphically) > 1000 mg/l

3h values:
oxygen consumption (mg02/l*h) 42,3
reference value (mg02/l*h) 36,4
delta (%) 16
EC20 (determined graphically) > 1000 mg/l

Description of key information

The inhibition of the degradation activity of activated sludge on sebacic acid is not anticipated when introduced in appropriate

low concentrations.

Key value for chemical safety assessment

Additional information

A short term respiration inhibition test conducted, in accordance with ISO 8192 [BASF AG, 1990]. After incubation of 3 hours no respiration inhibition observed up to the highest test concentration of 1000 mg/L sebacic acid.