Registration Dossier
Registration Dossier
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EC number: 203-845-5 | CAS number: 111-20-6
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
No mortalities or clinical signs were observed in the acute oral and dermal studies (LD50 (oral, rat) > 5000 mg/kg bw; LD50 (dermal, rabbit) > 2000 mg/kg bw). No dermal irritation and only slight but fully reversible ocular irritation were observed. Also a classification as skin sensitising was not required. Furthermore, no adverse effects were observed in the repetetive oral studies with rats and rabbits up to the limit dose of 1000 mg/kg bw (NOAEL (rat) >= 1000 mg/kg bw; NOAEL (rabbit) >= 1500 mg/kg bw). Mutagenicity in vitro or in vivo, teratogenicity and effects on fertility in rats and rabbits were also not observed.
Therefore, due to the lack of adverse effects up to the respective limit doses no threshold was identified for any toxicological endpoint. Consequently, no DNELs for workers or the general population have been derived.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
No mortalities or clinical signs were observed in the acute oral and dermal studies (LD50 (oral, rat) > 5000 mg/kg bw; LD50 (dermal, rabbit) > 2000 mg/kg bw). No dermal irritation and only slight but fully reversible ocular irritation were observed. Also a classification as skin sensitising was not required. Furthermore, no adverse effects were observed in the repetetive oral studies with rats and rabbits up to the limit dose of 1000 mg/kg bw (NOAEL (rat) >= 1000 mg/kg bw; NOAEL (rabbit) >= 1500 mg/kg bw). Mutagenicity in vitro or in vivo, teratogenicity and effects on fertility in rats and rabbits were also not observed.
Therefore, due to the lack of adverse effects up to the respective limit doses no threshold was identified for any toxicological endpoint. Consequently, no DNELs for workers or the general population have been derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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