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EC number: 204-211-0 | CAS number: 117-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
From the short-term toxicity studies it can be concluded that DEHP has no acute effect on fish at concentrations far exceeding its water solubility. Therefore, no LC50 can be derived.
Key value for chemical safety assessment
Additional information
The short term toxicity of DEHP to fish has been tested in different studies of varying quality. The RAR, 2008 reports all these studies. No new studies have been produced since then. Both static, semistatic and flow-through test regimes have been applied. In many of the tests there has been problems maintaining test concentrations.
In studies where both nominal and measured test concentrations are reported the measured concentrations are often lower. Therefore studies where only nominal test concentrations are reported may underestimate the toxicity of DEHP.
The key study is a work performed by Springborn Bionomics laboratories (1983 and 1984) and published by Adams et al. (1995). Studies were conducted in accordance with US EPA and GLP standards on 4 species of fish: Fathead minnow, Bluegill sunfish, Sheepshead minnow or Rainbow trout. Tests were performed in static or flow though conditions. No solvent was used and care was taken to avoid remaining floating test chemical. In all cases, no toxicity was observed at the level tested (mean measured concentrations between 0.16 and 0.67 mg/L). Therefore in short term exposure (96h) DEHP concentrations near or above the limit of water solubility of 3 µg/L do not induce hazardous effects to fish.
This result is supported by DeFoe et al. (1990) who showed no adverse nor anormal behaviour of Fathead minnows and Medaka exposed in flow through systems during 96h to saturated solution of DEHP (mean measured concentrations 0.326 and 0.67 mg/L, respectively). In his study report, Scholtz (1990) showed no toxicity even at the unrealistic environmental concentration of 100 mg/L. It shall be noted that, in several other studies, concentrations up to 3,000 mg/l have been tested without causing mortality. Only one study reported a LC50 for rainbow trout at the nominal concentration of 540 mg/l (Hrudey et al., 1976). The mortality in this study is assumed by the authors to be caused by physical action. Considering the physical effect and/or unrealistic concentration tested, these studies are considered as unreliable. However, these studies support that DEHP has no hazardous effect at concentration at or above its water solubility and if effects are observed at very high concentrations it is due to physical effects. Therefore, from the short-term toxicity studies it can be concluded that DEHP has no acute effect on fish at concentrations far exceeding its water solubility.
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