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EC number: 204-211-0 | CAS number: 117-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl) phthalate
- EC Number:
- 204-211-0
- EC Name:
- Bis(2-ethylhexyl) phthalate
- Cas Number:
- 117-81-7
- Molecular formula:
- C24H38O4
- IUPAC Name:
- 1,2-bis(2-ethylhexyl) benzene-1,2-dicarboxylate
- Details on test material:
- - Name of test material (as cited in study report): Di(2-ethylhexyl)phthalate
- Physical state: liquid
- Analytical purity: 95%
- Impurities: Results of thinlayer chrotuatography indicated one homogeneous spot, and those of vapor-phase chromatography indicated two minor impurities having a total area less than 0.5% of the major peak.
- Lot/batch No.: GC-2-26-76
- Stability under test conditions: Di(2-ethylhexyl)phthalate mixed with feed is stable for 2 weeks at temperatures of up to 45°C
- Source: W.R. Grace and Company (Fords, NJ)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: NCI Frederick Cancer Research Center, MD
- Age at study initiation: 5-6 weeks old
- Weight at study initiation: no data but equivalent in each group
- Fasting period before study: no data
- Housing: Rats and mice were housed five per cage in suspended polycarbonate cages equipped with disposable nonwoven fiber filter sheets. Hardwood chip bedding and cages were changed twice weekly, and cage racks were changed every 2 weeks.
- Diet (e.g. ad libitum): powdered Wayne Lab Blox® -meal in stainless-steel, gang-style hoppers that were changed once per week available ad libitum.
- Water (e.g. ad libitum): Water, supplied by an Edstrom automatic watering system available ad libitum.
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-31 (average 23°C)
- Humidity (%): 10-88
- Air changes (per hr): Incoming air was filtered through Tri-Dek 15/40 denier Dacron filters, with 10 room air changes per hour.
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: no data
MAXIMUM DOSE VOLUME APPLIED: no data - Doses:
- from 0.8 to 20 g/kg (details not available)
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data - Statistics:
- not appropriate
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 20 000 mg/kg bw
- Mortality:
- All animals survived the 14-day observation period.
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information LD0 > 20000 mg/kg bw Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008
- Conclusions:
- Under these experimental conditions, the oral LD0 of DEHP is higher than 20000 mg/kg in Fisher 344 rats.
- Executive summary:
The Acute oral toxicity of di(2-ethylhexyl)phthalate (DEHP) was evaluated in F344 rats according to a protocol similar to the OECD N°401 guideline. Groups of 5 male and 5 female Fisher 344 rats were given a single oral dose of DEHP at doses between 800 to 20000 mg/kg. Following treatment, rats were observed until D14. All animals survived the 14-day observation period. The oral LD0 of DEHP is higher than 20000 mg/kg in rats.
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