Ethyl acrylate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25 July 1985 - 19 Dec 1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions, conducted in compliance with GLP regulations (occlusive application, only males tested, no control)

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1994

Materials and methods

Principles of method if other than guideline:

Six rats per dose group (2000, 2514, 3162, 3976 and 5000 mg/kg bw) were treated with a single occluded application for 24 hours.

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl acrylate

EC Number:

205-438-8

EC Name:

Ethyl acrylate

Cas Number:

140-88-5

Molecular formula:

C5H8O2

IUPAC Name:

ethyl acrylate

Details on test material:

- Name of test material (as cited in study report): Ethyl acrylate
- Analytical purity: 99 %

Test animals

Species:

rat

Strain:

other: CD

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Lakeview
- Weight at study initiation: 256 g (mean over all dose groups), range (of group means): 207 - 290 g

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 h

Doses:

2000, 2514, 3162, 3976 and 5000 mg/kg bw

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

3 049 mg/kg bw

95% CL:

2 300 - 3 846

Mortality:

0, 3, 3, 5 and 5 animals died at dose levels of 2000, 2514, 3162, 3976 and 5000 mg/kg bw, respectively.

Clinical signs:

other: Animals in all dose groups exhibited red-stained eyes and muzzle. Passiveness, ataxia and tan-stained muzzle were observed in animals at doses as low as 2514 mg/kg. Salivation and yellow-stained anogenital area were observed in animals at doses as low as 

Gross pathology:

Necropsy findings in decedents included reddened intestine and adrenals, reddened stomach mucosa and presence of small amount of black solid in stomach. No gross changes were observed in the survivors.

Other findings:

Local Skin Findings: Skin irritation was noted in animals of all dose groups. Well defined to severe erythema and severe edema with pocketing were observed on Day 1. Pocketing edema was not longer evident on Day 4.  Edema was no longer evident on day 11. Eschar and desiccation were  observed on Day 4 and persisted throughout the study. Possible scar formation was observed on day 13 and persisted throughout the study.

Any other information on results incl. tables

Dosage [mg/kg bw]	Mortality	Body weight [g]
		at study initiation	at study termination
5000	5/6	207	288
3976	5/6	286	358
3162	3/6	288	326
2514	3/6	290	351
2000	0/6	209	288

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU