Registration Dossier
Registration Dossier
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EC number: 200-817-4 | CAS number: 74-87-3
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Long-term follow-up after methyl chloride intoxication.
- Author:
- Rafnsson, V. and Gudmundsson, G.
- Year:
- 1 997
- Bibliographic source:
- Arch Environ Health., 52(5):355-359, as cited in: OECD SIDS Chloromethane, 2004
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- carcinogenicity
- Principles of method if other than guideline:
- In this study, the authors investigated mortality and cancer patterns among a group of individuals accidentally exposed to methyl chloride 32 years earlier. This group of 24 persons had survived the immediate intoxication, which had occurred on a trawler during a fishing trip.
- GLP compliance:
- no
Test material
- Reference substance name:
- Chloromethane
- EC Number:
- 200-817-4
- EC Name:
- Chloromethane
- Cas Number:
- 74-87-3
- Molecular formula:
- CH3Cl
- IUPAC Name:
- chloromethane
- Details on test material:
- - Name of test material (as cited in study report): methyl chloride
- Analytical purity: no data
Constituent 1
Method
- Subjects:
- - Number of persons exposed: 24
- Route of exposure:
- inhalation
- Reason of exposure:
- accidental
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- The Mantel-Haenszel point estimate (M-H) was 2.2, and the 95% confidence interval (CI) was 1.3-3.1 for all causes of death.
There was an excess of deaths from cardiovascular diseases (M-H = 2.1, 95% CI = 1.2-3.8). This excess mortality was more prominent among deckhands who had been subject to higher exposure; risk ratios (RRs) were elevated for all causes of death (RR = 2.5, 95% CI = 1.0-5.7), as well as for cardiovascular diseases (RR = 3.9, 95% CI = 1.0-14.4).
In addition, the authors noted elevated risks for all cancers (M-H = 1.5, 95% CI = 0.3-5.6) and for lung cancer (M-H = 2.7, 95% CI = 0.1-52.6).
The authors discussed their results in the context of a possible relationship between the incidence of cardiovascular disease and exposure to chloromethane, although any relationship between the two, based on their data, appeared marginal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
