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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature

Data source

Reference
Reference Type:
publication
Title:
The excretion in breath of some aliphatic halogenated hydrocarbons following administration by inhalation.
Author:
Morgan, A., et al.
Year:
1970
Bibliographic source:
Ann Occup. Hyg. 13:219-233, as cited in: OECD SIDS Chloromethane, 2004

Materials and methods

Type of study / information:
Type of experience: Human
Endpoint addressed:
basic toxicokinetics
Principles of method if other than guideline:
After inhalation as a single breath of 38C-chloromethane by volunteers, to assess distribution and excretion.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloromethane
EC Number:
200-817-4
EC Name:
Chloromethane
Cas Number:
74-87-3
Molecular formula:
CH3Cl
IUPAC Name:
chloromethane
Details on test material:
- Name of test material (as cited in study report):  38C-chloromethane
- Analytical purity: no data

Results and discussion

Results:
After inhalation as a single breath of 38C-chloromethane by volunteers, 29% of the inhaled radioactivity was excreted in expired air within one hour. The urinary excretion was < 0.01%/min. Chloromethane was shown to be slower in excretion than predicted based on the blood: air partition coefficient, suggesting it reacts with substances in the bloodstream.

Applicant's summary and conclusion