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Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

From the available test data in combination with the QSAR calculation it can be concluded, that the substance shows a very low long-term toxicity to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
Effect concentration:
8 590 mg/L

Additional information

Data on long-term effects to aquatic invertebrates are available for ethylene glycol ([Pillard, 1995).

The study with ethylene glycol was conducted according to EPA guideline 600/4-89/001 with Ceriodaphnia dubia as test specie. This test was terminated when 60% of the control organisms had produced three broods. After a test duration of 7 days the NOEC for reproduction was determined to be 8590 mg/L for ethylene glycol (nominal, Pillard, 1995).

No analytical monitoring was performed during the test study; however, the test substance is expected to be stable in water based on its physicochemical properties:

The Substance has a sufficiently high water solubility (miscible, cited in HSDB Database, see IUCLID Ch. 4.8). Adsorption is not expected based on the low log Kow (-1.36, cited in HSDB Database, see IUCLID Ch. 4.7) and log Koc (log Koc = -1.03; estimated; EPI Suite v4.11, KOCWIN v2.00, BASF SE, 2021). The Substance is not expected to evaporate from the test solution based on its low Henry's Law Constant (HLC = 0.1327 Pa m³/mol, 25 °C, estimated; EPI Suite v4.11, HENRYWIN v3.20; in applicability domain; BASF SE, 2021) and its low vapor pressure (VP = 0.123 hPa, cited in HSDB Database, see IUCLID Ch. 4.6).

Additionaly, for the test substance the long-term toxicity to aquatic invertebrates was determined using a valid QSAR model (ECOSAR v2.0; BASF SE, 2022). The ChV for the test substance was predicted to be 909 mg/L. The substance is within the applicability domain of the model.

Overall, experimental and estimated chronic values are clearly greater than 1 mg/L with regard to classification limits and also greater than 10 mg/L, which the limit concentration in long-term toxicity testing; therefore, long-term effects on aquatic invertebrates are not to be expected.