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EC number: 204-587-6 | CAS number: 122-97-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on weight of evidence approaches the LD50 for oral and dermal application of the test substance were found to be > 2000 mg/kg bw and < 5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- old report but sufficient for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150 - 300 g - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 % - Doses:
- 1470, 2150, 3160 and 4640 mg/kg bw
- No. of animals per sex per dose:
- 10 animals in the 5000 mg/kg group and 5 animals in each of the other groups were used.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 250 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 680 - < 3 000
- Mortality:
- In the 5000 mg/kg bw dose group, 9/10 animals died. Mortality occured in all dose groups.
- Clinical signs:
- other: Clinical signs observed were depression, hypopnea, ataxia and piloerection.
- Gross pathology:
- Some of the dead rats and of those that were sacrifieced at termination had dark red areas in the lungs.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study in rats, the LD50 was found to be 2250 mg/kg bw.
- Executive summary:
An acute oral toxicity study was conducted on rats. First, a dose of 5000 mg/kg bw was tested and 9/10 animals died. Afterwards the following doses were applied: 1470, 2150, 3160 and 4640 mg/kg bw. Depression, hypopnea, ataxia and piloerection were observed and some of the dead animals or those who were sacrificed after study termination had dark red areas in the lungs. Mortality occured in all dose groups. Based on the available results, the LD50 was determined to be 2250 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- old summary of a study report, basic information given
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: individually
- Diet: commercial diet ad libitum
- Water: ad libitum - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Toxic signs and mortalitiy were recorded daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- The LD50 value was calculated according to Horn's method (Horn, H.J.,Biometric, 12: 311-322, 1956).
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- < 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 9/10 animals died
- Clinical signs:
- other: Depression, hypopnea, ataxia, piloerection
- Gross pathology:
- Dead rats showed distended stomach.
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The LD50 was found to be below 5000 mg/kg bw.
- Executive summary:
10 rats were adiminstered the test substance at a concentration of 5000 mg/kg bw. As a result, the animals showed depression, hypopnea, ataxia and piloerection and 9 animals died. The dead rats showed distended stomachs. As a result, the LD50 was determined to be <5000 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- short summary of study results including only basic information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 670, 1310, 2560, 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals per dose (sex not specified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs - Statistics:
- The LD50 was calculated.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 500 - < 3 100
- Mortality:
- 1 animal in 1310 mg/kg bw dose group died on day 1; 4 from the 2560 mg/kg bw dose group died on day 1 and 1 animal died on day 2; all animals of the 5000 mg/kg bw dose group died on day 1.
- Clinical signs:
- other: Lethargy was observed from the 1310 mg/kg bw dose group onwards.
- Gross pathology:
- no data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study in rats the LD50 value was found to be 2300 mg/kg bw.
- Executive summary:
An acute oral toxicity study was conducted on rats. The test substance was applied to 4 groups of 10 rats each in the following concentrations: 670, 1310, 2560 and 5000 mg/kg bw. Lethargy was observed from the 1310 mg/kg bw dose group onwards. All animals of the highest dose group died on day 1 of the study as well as one animal of the 1310 mg/kg bw dose group. 5 animals of the 12560 mg/kg bw dose group died on days 1 and 2. Based on these results, the LD50 was found to be 2300 mg/kg bw.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 250 mg/kg bw
- Quality of whole database:
- Old unpublished reports, but basic data given and sufficient for assessment.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: individually
- Diet: commercial diet ad libitum
- Water: ad libitum - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 240 cm2
- % coverage: 10
- Type of wrap if used: rubber sleeve covered with Webril padding
TEST MATERIAL
- Amount applied: 5000 mL/kg bw - Duration of exposure:
- 24 h
- Doses:
- 5000 mL/kg bw
- No. of animals per sex per dose:
- 6 animals
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 4 of 6 animals died on days 1, 3 and 4.
- Clinical signs:
- other: No toxic signs were observed in the surviving animals during the 14 day observation period.
- Gross pathology:
- The lungs appeared hemorrhagic in 2 animals that had died, 1 animal had white nodules in the liver, in one female both ovaries appeared abscessed.
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In an acute dermal toxicity study the LD50 was found to be <5000 mg/kg bw.
- Executive summary:
An acute dermal toxicity study was conducted on 6 New Zealand white rabbits. 5000 mL/kg bw were applied to the clipped skin sites under occlusion for 24 hours. After this exposure period, the animals were observed for 14 days. 2 rabbits died on day one and two further animals died on days 2 and 3. In two of this animals, the lungs were found to be hemorrhagic, one animal had white nodules in the liver and the ovaries of one female appeared abscessed. Clinical signs were not observed during the whole observation period in the surviving animals. Based on this result, the LD50 value was determined to be < 5000 mg/kg bw.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- summary of study results, basic information given
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Details on dermal exposure:
- TEST MATERIAL
- Amount applied: 2500 mg/kg bw and 5000 mg/kg bw - Duration of exposure:
- no data
- Doses:
- 2500 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 4 animals in the low dose group, 6 animals in the high dose group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs - Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured in the lower dose group, 3 of 6 animals died in the high dose group.
- Clinical signs:
- other: One rabbit of the high dose group exhibited slight lethargy and one showed flaccid tone. Anorexia and diarrhea were observed in 2 animals.
- Gross pathology:
- no data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study the LD50 of the test substance was determined to be approximately 5000 mg/kg bw.
- Executive summary:
The test substance was dermally adminstered to rabbits to evaluate the LD50 value. 2500 mg/kg bw were applied to 4 animals and 5000 mg/kg bw were applied to 6 animals. In the low dose group, no animals died and no clinical signs were observed. In the high dose group, slight lethargy, anorexia, diarrhea and flaccid tone were observed and 3 rabbits died. Based on these results, the LD50 value was determined to be approximately 5000 mg/kg bw.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Old unpublished reports, but basic data given and sufficient for assessment.
Additional information
Acute Toxicity: oral
An acute oral toxicity study was conducted on rats. First, a dose of 5000 mg/kg bw was tested and 9/10 animals died. Afterwards the following doses were applied: 1470, 2150, 3160 and 4640 mg/kg bw. Depression, hypopnea, ataxia and piloerection were observed and some of the dead animals or those who were sacrificed after study termination had dark red areas in the lungs. Mortality occured in all dose groups. Based on the available results, the LD50 was determined to be 2250 mg/kg bw.
10 rats were adiminstered the test substance at a concentration of 5000 mg/kg bw. As a result, the animals showed depression, hypopnea, ataxia and piloerection and 9 animals died. The dead rats showed distended stomachs. As a result, the LD50 was determined to be < 5000 mg/kg bw.
An acute oral toxicity study was conducted on rats. The test substance was applied to 4 groups of 10 rats each in the following concentrations: 670, 1310, 2560 and 5000 mg/kg bw. Lethargy was observed from the 1310 mg/kg bw dose group onwards. All animals of the highest dose group died on day 1 of the study as well as one animal of the 1310 mg/kg bw dose group. 5 animals of the 12560 mg/kg bw dose group died on days 1 and 2. Based on these results, the LD50 was found to be 2300 mg/kg bw.
As a conclusion, the LD50 was found to be > 2000 mg/kg bw and < 5000 mg/kg bw.
Acute toxicity: dermal
An acute dermal toxicity study was conducted on 6 New Zealand white rabbits. 5000 mL/kg bw were applied to the clipped skin sites under occlusion for 24 hours. After this exposure period, the animals were observed for 14 days. 2 rabbits died on day one and two further animals died on days 2 and 3. In two of this animals, the lungs were found to be hemorrhagic, one animal had white nodules in the liver and the ovaries of one female appeared abscessed. Clinical signs were not observed during the whole observation period in the surviving animals. Based on this result, the LD50 value was determined to be < 5000 mg/kg bw.
The test substance was dermally adminstered to rabbits to evaluate the LD50 value. 2500 mg/kg bw were applied to 4 animals and 5000 mg/kg bw were applied to 6 animals. In the low dose group, no animals died and no clinical signs were observed. In the high dose group, slight lethargy, anorexia, diarrhea and flaccid tone were observed and 3 rabbits died. Based on these results, the LD50 value was determined to be approximately 5000 mg/kg bw.
As a conclusion, the LD50 was found to be ca. 5000 mg/kg bw.
Justification for classification or non-classification
On the basis of the available data the substance is not considered to be classified for acute oral toxicity under Regulation (EC) No 1272/2008 (CLP), as amended for the tenth time in Regulation (EC) No 2017/776.
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