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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
old report but sufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-phenylpropan-1-ol
EC Number:
204-587-6
EC Name:
3-phenylpropan-1-ol
Cas Number:
122-97-4
Molecular formula:
C9H12O
IUPAC Name:
3-phenylpropan-1-ol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 150 - 300 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 50 %
Doses:
1470, 2150, 3160 and 4640 mg/kg bw
No. of animals per sex per dose:
10 animals in the 5000 mg/kg group and 5 animals in each of the other groups were used.
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 250 mg/kg bw
Based on:
test mat.
95% CL:
> 1 680 - < 3 000
Mortality:
In the 5000 mg/kg bw dose group, 9/10 animals died. Mortality occured in all dose groups.
Clinical signs:
other: Clinical signs observed were depression, hypopnea, ataxia and piloerection.
Gross pathology:
Some of the dead rats and of those that were sacrifieced at termination had dark red areas in the lungs.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an acute oral toxicity study in rats, the LD50 was found to be 2250 mg/kg bw.
Executive summary:

An acute oral toxicity study was conducted on rats. First, a dose of 5000 mg/kg bw was tested and 9/10 animals died. Afterwards the following doses were applied: 1470, 2150, 3160 and 4640 mg/kg bw. Depression, hypopnea, ataxia and piloerection were observed and some of the dead animals or those who were sacrificed after study termination had dark red areas in the lungs. Mortality occured in all dose groups. Based on the available results, the LD50 was determined to be 2250 mg/kg bw.