Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Short-term fish

Key study: MITI, 2000, 9B506G; OECD 203, Oryzias latipes: 96-h LC50 = 22.6 mg/L (nominal, analytically verified). 

Based on this result, phthalonitrile is considered to be acutely harmful to fish.


Long-term fish

No data. Not required for this tonnage band.


Short-term aquatic invertebrates

KEY study: MITI, 1999, 9B462G; OECD 202, Daphnia magna: 48-h EC50 = 211 mg/L (nominal, analytically verified). 

Based on the available results the substance is with high probability acutely not harmful to aquatic organisms.


Long-term aquatic invertebrates

Key study: MITI, 2000, 9B484G; OECD 211, Daphnia magna: 21-d NOEC = 14 mg/L, 21-d EC50 = 48.5 mg/L (nominal, analytically verified). 

Based on CLP, chronic toxicity to aquatic invertebrates is not anticipated.


Toxicity to aquatic algae and cyanobacteria

Key study: MITI, 2000, 9B440G; OECD 201, Pseudokirchneriella subcapitata, (previous name Selenastrum capricornutum). Re-calculation with ToxRat Pro v3.3.0:72-h EC10= 78.3 mg/L, 72-h EC50 = 141.1 mg/L.

Based on the available data phthalonitrile is not considered to be acutely harmful to aquatic algae. Additionally, following CLP chronic toxicity is not anticipated.


Toxicity to microorganisms

Key study: BASF AG (1987), ISO 8192, inoculum: domestic activated sludge. 30-m EC20 >100 mg/l.

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.