Registration Dossier
Registration Dossier
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EC number: 202-044-8 | CAS number: 91-15-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Chromosomenuntersuchungen bei Mitarbeitern mit Exposition • gegenüber ortho-Phthalodinitril (o-PDN)
- Author:
- Fleig I. and A.M. Thiess
- Year:
- 1 979
- Bibliographic source:
- Zbl. Arbeitsmed. 5, 127-129
Materials and methods
- Principles of method if other than guideline:
- Method: other: human Lymphocytes
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Phthalonitrile
- EC Number:
- 202-044-8
- EC Name:
- Phthalonitrile
- Cas Number:
- 91-15-6
- Molecular formula:
- C8H4N2
- IUPAC Name:
- benzene-1,2-dicarbonitrile
Constituent 1
Test animals
- Species:
- other: human
Administration / exposure
- Route of administration:
- other: contamination (dermal exposure, inhalation)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
Basis:
Results and discussion
Any other information on results incl. tables
RS-Freetext:
Negative, no increase of chromosomal aberration.
Applicant's summary and conclusion
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