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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Chromosomenuntersuchungen bei Mitarbeitern mit Exposition • gegenüber ortho-Phthalodinitril (o-PDN)
Author:
Fleig I. and A.M. Thiess
Year:
1979
Bibliographic source:
Zbl. Arbeitsmed. 5, 127-129

Materials and methods

Principles of method if other than guideline:
Method: other: human Lymphocytes
GLP compliance:
not specified
Type of assay:
chromosome aberration assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Phthalonitrile
EC Number:
202-044-8
EC Name:
Phthalonitrile
Cas Number:
91-15-6
Molecular formula:
C8H4N2
IUPAC Name:
benzene-1,2-dicarbonitrile

Test animals

Species:
other: human

Administration / exposure

Route of administration:
other: contamination (dermal exposure, inhalation)
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
Basis:

Results and discussion

Any other information on results incl. tables

RS-Freetext:
Negative, no increase of chromosomal aberration.

Applicant's summary and conclusion