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PBT assessment

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PBT assessment: overall result

Reference
Name:
1,​3-​Propanediol, 2,​2-​bis(hydroxymethyl)​-​, allyl ether
Type of composition:
legal entity composition of the substance
State / form:
liquid
Reference substance:
1,​3-​Propanediol, 2,​2-​bis(hydroxymethyl)​-​, allyl ether
Reference substance:
1,​3-​Propanediol, 2,​2-​bis(hydroxymethyl)​-​, allyl ether
Reference substance:
1,​3-​Propanediol, 2,​2-​bis(hydroxymethyl)​-​, allyl ether
PBT status:
further information relevant for the PBT assessment is necessary
Justification:

 


The results of an OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test) concluded that 1, 3- Propanediol, 2, 2- bis(hydroxymethyl) - , allyl ether is not readily biodegradable. Further information is required until a conclusion can be made on P properties. Simulation testings on ultimate degradation in surface water (OECD 309) has therefore been proposed. 


Data are available for the log Pow of the main components at 25°C, with the two main components log Pow values ranging from 1.5 to 3.0 and the third component showing a log Pow value of 4.8, thus the bioaccumulation potential of 1, 3- Propanediol, 2, 2- bis(hydroxymethyl) - , allyl ether is considered uncertain based on log Pow alone. The bioaccumulation potential was therefore estimated in the VEGA software (version 1.2.3) using the CAESAR (version 2.1.14) and NN/Read-Across (version 1.1.0) QSAR models, however these predictions were shown to be unreliable. It is therefore considered that there is currently insufficient information on the bioaccumulation potential of 1,3-propanediol, 2,2- bis(hydroxymethyl) -, allyl ether to conclude whether the substance is bioaccumulative (B/vB). An OECD Guideline 305 study has therefore been proposed.


 


Short-term ecotoxicology data are available, showing L(E)C50 values of 52 mg/L (fish, 96-h LC50), 69.9 mg/L (Daphnia, 48-h EC50) and >100 mg/L (algae, 72-h EC50). Long-term ecotoxicity data are not available. Based on available short-term ecotoxicity data, the substance does not meet the criteria to be considered potentially toxic (T) (i.e. L(E)C50 values are not <0.1 mg/l). It is therefore concluded that 1, 3- Propanediol, 2, 2- bis(hydroxymethyl) - , allyl ether is not T under PBT.