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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according to accepted scientific standards
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996
Reference Type:
secondary source
Title:
O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment
Author:
Bomhard, E. M. et al.
Year:
2002
Bibliographic source:
Crit. Rev. Toxicol. 32(6):551-626

Materials and methods

Principles of method if other than guideline:
Absorption through skin and subsequent metabolism and excretion was investigated in human volunteers
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl-2-ol
EC Number:
201-993-5
EC Name:
Biphenyl-2-ol
Cas Number:
90-43-7
Molecular formula:
C12H10O
IUPAC Name:
2-phenylphenol
Radiolabelling:
yes
Remarks:
14C

Test animals

Species:
human
Sex:
male

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: 2-propanol
Duration of exposure:
8 hours
Control animals:
no

Results and discussion

Percutaneous absorption
Key result
Time point:
8 h
Dose:
0.006 mg OPP/kg bw
Parameter:
percentage
Absorption:
43.15 %
Remarks on result:
other: human
Conversion factor human vs. animal skin:
not applicable

Applicant's summary and conclusion