Sodium 2-biphenylate

Dermal absorption

Administrative data

Endpoint:

dermal absorption in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1996

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study according to accepted scientific standards

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1996

Report date:

1996

Reference 2

Reference Type:

secondary source

Title:

O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment

Author:

Bomhard, E. M. et al.

Year:

2002

Bibliographic source:

Crit. Rev. Toxicol. 32(6):551-626

Materials and methods

Principles of method if other than guideline:

Absorption through skin and subsequent metabolism and excretion was investigated in human volunteers

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Biphenyl-2-ol

EC Number:

201-993-5

EC Name:

Biphenyl-2-ol

Cas Number:

90-43-7

Molecular formula:

C12H10O

IUPAC Name:

2-phenylphenol

Radiolabelling:

yes

Remarks:

14C

Test animals

Species:

human

Sex:

male

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

other: 2-propanol

Duration of exposure:

8 hours

Control animals:

no

Results and discussion

Percutaneous absorption

Key result

Time point:

8 h

Dose:

0.006 mg OPP/kg bw

Parameter:

percentage

Absorption:

43.15 %

Remarks on result:

other: human

Conversion factor human vs. animal skin:

not applicable