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Short-term toxicity to aquatic invertebrates

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In a GLP study conducted according to OECD Guideline 202, the 48-h NOEC of trisodium EDDS for mobility and swimming behaviour of the freshwater crustacean, Daphnia magna, was 1000 mg/L (the highest tested concentration) and 320 mg/L, respectively. After 48 h exposure, all daphnids were mobile at all the tested concentrations, therefore the 48-h EC50 would be >1000 mg/L.

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Additional information

In a GLP study conducted according to OECD Guideline 202, the acute toxicity of trisodium EDDS to the freshwater crustacean, Daphnia magna, was assessed. The test was carried out with 4 beakers each containing 5 daphnids for each test concentration, and the test solutions were not replaced. The exposure duration was 48 h. The animals were assessed for mobility and condition (swimming behaviour, colour, respiratory function or other visually observable morphological or behavioural criterion) at 0, 24 and 48 h. The nominal concentrations tested were 0, 100, 180, 320, 560 and 1000 mg/L. All test solutions were completely clear (visually assessed) throughout the test.

After 48 h exposure all daphnids were mobile at all the tested concentrations (therefore the 48-h EC50 would be >1000 mg/L). Regarding swimming behaviour, at 560 and 1000 mg/L the daphnids swam slower with irregular movements, and at 1000 mg/L they were paler in appearance than controls. Therefore, under the conditions of this study, the 48-h NOEC for trisodium EDDS for mobility and behaviour of Daphnia magna were 1000 mg/L and 320 mg/L, respectively (Hooftman and van Drongeien-Sevenhuijsen, 1993).

No data in marine invertebrates are currently available for EDDS acid or its trisodium salt.

[Data on trisodium EDDS is considered relevant to use for understanding the potential toxicity to aquatic invertebrates of EDDS acid, and is acceptable for using as read-across information].