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Long-term toxicity to aquatic invertebrates

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Description of key information

In a GLP study, similar to OECD Guideline 211 and EU Method C.20, the 21-d NOEC for trisodium EDDS for effects on reproduction, survival, condition and size to Daphnia magna in freshwater was 32 mg/L.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
32 mg/L

Additional information

In a GLP study, similar to OECD Guideline 211 and EU Method C.20, the reproductive toxicity of trisodium EDDS to the freshwater crustacean, Daphnia magna, was assessed. Ten daphnids (individually exposed) were used for each test concentration and the exposure duration was 21 d. The test was carried out under semi-static conditions with replacement of the test solutions three times per week. The nominal concentrations tested were 0, 0.32, 1.0, 3.2, 10, 32 and 100 mg/L. In addition to the quantitatively determined effects on survival and reproduction, effects on size and condition (swimming behaviour, colour or any other observable morphological or behavioural criterion) were visually estimated. The 21-d NOEC for effects on reproduction (less than 25% inhibition), survival, condition and size was 32 mg/L, the 21-d EC50 for effects on reproduction was calculated to be 80 mg/L, and the 21-d LC50 for survival was >100 mg/L (Hooftman and Kauffmanvan Bommel, 1994).

No data in marine invertebrates are currently available for EDDS acid or its trisodium salt.

[Data on trisodium EDDS is considered relevant to use for understanding the potential toxicity to aquatic invertebrates of EDDS acid, and is acceptable for using as read-across information].