Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 204-648-7 | CAS number: 123-75-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication, but insufficient data for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- p 425 - 429
- Author:
- Brambilla, G
- Year:
- 1 981
- Bibliographic source:
- Carcinogenesis 2
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: other: Alkaline elution assay
- GLP compliance:
- not specified
- Type of assay:
- other: DNA damage
Test material
- Reference substance name:
- Pyrrolidine
- EC Number:
- 204-648-7
- EC Name:
- Pyrrolidine
- Cas Number:
- 123-75-1
- Molecular formula:
- C4H9N
- IUPAC Name:
- pyrrolidine
- Details on test material:
- - Purity: 99 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- single
Doses / concentrations
- Remarks:
- Doses / Concentrations:
300 mg/kg
Basis:
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Remarks:
- Test concentration = LD50 concentration
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
negative; DNA damaging potency: 0.47
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
