Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
skin sensitisation: in vitro
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
an in vitro skin sensitisation study does not need to be conducted because adequate data from an in vivo skin sensitisation study are available
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Only one study on animals with reliability 3 was available (Goldberg, 1963). This study showed that guaiacol is not a skin sensitizer and was considered as a weight of evidence one regarding human data (Kligman, 1978). In Kligman, 1978 study which is considered as a key study, no signs of sensitization were observed on 25 healthy adult volunteers after a patch test with gaiacol.

Based on these studies, gaiacol is not considered as sensitizing.

Justification for classification or non-classification

Gaiacol is considered as not sensitizing (published data) based on one animal and one human study.