Tetraethylammonium heptadecafluorooctanesulphonate

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: well documented and scientifically acceptable

Data source

Reference

Reference Type:

publication

Title:

Serum concentrations of 11 polyfluoralkyl compounds in the U.S. population: data from the National Health and Nutrition examination survey (NHANES) 1999-2000

Author:

Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Tully JS, Needham LL

Year:

2007

Bibliographic source:

Environ Sci Technol 41, 2237-2242

Materials and methods

Study type:

biological exposure monitoring

Endpoint addressed:

not applicable

Principles of method if other than guideline:

The concentrations of 11 polyfluoroalkyl compounds (PFCs), including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) were measured in 1562 serum samples collected from a representative U.S. population 12 years of age and older in the 1999-2000 National Health and Nutrition
Examination Survey

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Heptadecafluorooctane-1-sulphonic acid

EC Number:

217-179-8

EC Name:

Heptadecafluorooctane-1-sulphonic acid

Cas Number:

1763-23-1

IUPAC Name:

1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonic acid

Details on test material:

perfluorooctane sulfonic acid (PFOS)

Method

Details on study design:

Survey Design.
NHANES 1999-2000 was a complex, multistage probability survey conducted in 26 locations throughout the United States that included examinations of 9282 people. Informed written consent was obtained from all participants. Serum samples analyzed for PFCs were obtained by venipuncture from 1562 people, a random onethird subsample of participants 12 years of age and older. Because the subsample was a random selection from the entire set, the representational aspect of the survey was maintained.

Results and discussion

Results:

PFOS, PFOA, PFHxS, and PFOSA were detected in all 1562 persons. PFOS demonstrated the highest serum concentrations followed by PFOA and PFHxS. PFNA, Et-PFOSA-AcOH, andMe-PFOSA-AcOH were detected in more than 90% of the samples examined. These findings confirm that exposures to PFOS, PFOA, PFHxS, and four other PFCs were widespread in the U.S. general population during 1999-2000.

Any other information on results incl. tables

The concentrations of most PFCs were similar regardless of the participants’ ages but were higher in males than in females. Mexican Americans had lower concentrations than non-Hispanic blacks and non- Hispanic whites, whose concentrations were similar

Applicant's summary and conclusion

Executive summary:

We measured the concentrations of 11 polyfluoroalkyl compounds (PFCs), including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) in 1562 serum samples collected from a representative U.S. population 12 years of age and older in the 1999-2000 National Health and Nutrition Examination Survey. Participants represented both sexes, three race/ethnicities (non-Hispanic blacks, non-Hispanic whites, and Mexican-Americans), and four age categories (12-19 years, 20-39 years, 40-59 years, and 60 years and older). PFCs were extracted from 100 íL of serum using on-line solid-phase extraction coupled to isotope dilutionhigh performance liquid chromatography-tandem mass spectrometry; limits of detection ranged from 0.05 to 0.2 ng/ mL. PFOS, PFOA, PFHxS, and perfluorooctane sulfonamide were detected in all samples analyzed; 2-(N-ethylperfluorooctane sulfonamido) acetic acid, 2-(N-methylperfluorooctane sulfonamido) acetic acid, and perfluorononanoic acid were detected in more than 90% of samples, which suggests prevalent exposures to several PFCs in the U.S. population. The concentrations of most PFCs were similar regardless of the participants’ ages but were higher in males than in females. Mexican Americans had lower concentrations than non-Hispanic blacks and non- Hispanic whites, whose concentrations were similar. Higher education was associated with higher concentrations of PFOS and PFOA.