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EC number: 260-375-3 | CAS number: 56773-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Reference
- Reference Type:
- publication
- Title:
- Serum concentrations of 11 polyfluoralkyl compounds in the U.S. population: data from the National Health and Nutrition examination survey (NHANES) 1999-2000
- Author:
- Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Tully JS, Needham LL
- Year:
- 2 007
- Bibliographic source:
- Environ Sci Technol 41, 2237-2242
Materials and methods
- Study type:
- biological exposure monitoring
- Endpoint addressed:
- not applicable
- Principles of method if other than guideline:
- The concentrations of 11 polyfluoroalkyl compounds (PFCs), including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) were measured in 1562 serum samples collected from a representative U.S. population 12 years of age and older in the 1999-2000 National Health and Nutrition
Examination Survey - GLP compliance:
- no
Test material
- Reference substance name:
- Heptadecafluorooctane-1-sulphonic acid
- EC Number:
- 217-179-8
- EC Name:
- Heptadecafluorooctane-1-sulphonic acid
- Cas Number:
- 1763-23-1
- IUPAC Name:
- 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonic acid
- Details on test material:
- perfluorooctane sulfonic acid (PFOS)
Constituent 1
Method
- Details on study design:
- Survey Design.
NHANES 1999-2000 was a complex, multistage probability survey conducted in 26 locations throughout the United States that included examinations of 9282 people. Informed written consent was obtained from all participants. Serum samples analyzed for PFCs were obtained by venipuncture from 1562 people, a random onethird subsample of participants 12 years of age and older. Because the subsample was a random selection from the entire set, the representational aspect of the survey was maintained.
Results and discussion
- Results:
- PFOS, PFOA, PFHxS, and PFOSA were detected in all 1562 persons. PFOS demonstrated the highest serum concentrations followed by PFOA and PFHxS. PFNA, Et-PFOSA-AcOH, andMe-PFOSA-AcOH were detected in more than 90% of the samples examined. These findings confirm that exposures to PFOS, PFOA, PFHxS, and four other PFCs were widespread in the U.S. general population during 1999-2000.
Any other information on results incl. tables
The concentrations of most PFCs were similar regardless of the participants’ ages but were higher in males than in females. Mexican Americans had lower concentrations than non-Hispanic blacks and non- Hispanic whites, whose concentrations were similar
Applicant's summary and conclusion
- Executive summary:
We measured the concentrations of 11 polyfluoroalkyl compounds (PFCs), including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) in 1562 serum samples collected from a representative U.S. population 12 years of age and older in the 1999-2000 National Health and Nutrition Examination Survey. Participants represented both sexes, three race/ethnicities (non-Hispanic blacks, non-Hispanic whites, and Mexican-Americans), and four age categories (12-19 years, 20-39 years, 40-59 years, and 60 years and older). PFCs were extracted from 100 íL of serum using on-line solid-phase extraction coupled to isotope dilutionhigh performance liquid chromatography-tandem mass spectrometry; limits of detection ranged from 0.05 to 0.2 ng/ mL. PFOS, PFOA, PFHxS, and perfluorooctane sulfonamide were detected in all samples analyzed; 2-(N-ethylperfluorooctane sulfonamido) acetic acid, 2-(N-methylperfluorooctane sulfonamido) acetic acid, and perfluorononanoic acid were detected in more than 90% of samples, which suggests prevalent exposures to several PFCs in the U.S. population. The concentrations of most PFCs were similar regardless of the participants’ ages but were higher in males than in females. Mexican Americans had lower concentrations than non-Hispanic blacks and non- Hispanic whites, whose concentrations were similar. Higher education was associated with higher concentrations of PFOS and PFOA.
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