Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995
Report date:
1995

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
5 male rats received 200 mg/kg bw and 5 females received 200 or 2000 mg/kg bw tetraethylammoniumperfluoroctansulfonate as a single oral application by gavage, substance was dissolved in H2O (2 ml/100 g bw); observation time: 14 d, calculation of LD50 according Spearman-Kaerber cited in Sachs L (Angewandte Statistik, 6. Aufl. 1984, p.178)
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetraethylammonium heptadecafluorooctanesulphonate
EC Number:
260-375-3
EC Name:
Tetraethylammonium heptadecafluorooctanesulphonate
Cas Number:
56773-42-3
Molecular formula:
C8H20N.C8F17O3S
IUPAC Name:
N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate
Details on test material:
content: 99.5/98.9%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
200, 2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
> 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: highest applied dose
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 632 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

signs of intoxication after application of 2000 mg/kg bw to female rats were ruffle fur, staggering gait, poor general condition, bloody snout and clonical convulsions. On female rats the body weight decreased in the first weak, afterwards body weight gain was normal.

A single oral application of 200 mg/kg bw were tolerated without symptoms

Applicant's summary and conclusion

Executive summary:

method: single orale application per gavage of test substance (dose 200 mg/kg bw to 5 male rats and 200 or 2000 mg/kg bw to female rats, post-observation time 14 days

result: LD50 = 632 mg/kg bw (female rats); LD50 > 200 mg/kg bw (male rats)