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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

Biodegradability was assessed in a guideline OECD 301D study (key study) as well as two additional supporting studies.

Key value for chemical safety assessment

Additional information

In the key study, no biodegradation of the test compound was observed. In a supporting study, the amount of test compound biodegraded over 7, 15 and 28 days based on BOD was 7%, 7%, and 9%, respectively. Primary biodegradation (i.e. loss of parent compound) based on GC analysis was 18% over 28 days. 1-Nitropropane is not readily biodegradable. In the 1990 supporting study, 1- nitropropane was degraded by 5.6%, 29.8% and 45.1% after 5, 15, and 28 days, respectively in a similar OECD 301D closed bottle test. Therefore, the material was degraded, but did not degrade enough to be classified as readily biodegradable. In the 1987 supporting study, 50 ug/L radiolabeled test compound was added to 1000 mg/L activated sludge and the radiolabeled CO2 was collected in traps. The amount of material degraded to 14CO2 after 5 days was 20.2% and 26.4%, for an average of 23.3%. The results of the three biodegradation studies indicate that 1-nitropropane meets the criteria of inherent, primary biodegradability as described in the OECD guidelines.