Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication but only limited data is given.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1969

Materials and methods

Principles of method if other than guideline:
Method: according to Smyth, Carpenter, Weil, Pozzani and Striegel: Range-Finding Toxicity Data: List VI, Amer. Ind. Hyg. Assoc. J. 23: 95 (1962) for details see any other information on materials and methods
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[2-(3-aminopropoxy)ethoxy]ethanol
EC Number:
203-960-0
EC Name:
2-[2-(3-aminopropoxy)ethoxy]ethanol
Cas Number:
112-33-4
Molecular formula:
C7H17NO3
IUPAC Name:
2-[2-(3-aminopropoxy)ethoxy]ethan-1-ol
Details on test material:
- Name of test material (as cited in study report): 3-Aminopropoxy-2-ethoxy ethanol

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
TEST SITE
- Area of exposure: clipped skin on the trunk
- Type of wrap if used: impervious plastic film

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data
Duration of exposure:
24 hours
Doses:
no data
No. of animals per sex per dose:
4 males
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
Statistics:
Based upon mortalities during a 14 day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson (Thompson W.R.: Use of Moving Averages and Interpolation to estimate Median Effective Dose, Bacteriol. Rev. 11: 115, June 1947) using Tables of Weil (Weil C. S.: Tables for convenient calculation of Median-Effective Dose (LD50 or ED50) and Instructions in their Use, Biometrics 8: 249, Sept. 1952).

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
5.99 mL/kg bw
Based on:
test mat.
95% CL:
4.27 - 8.42
Sex:
male
Dose descriptor:
LD50
Effect level:
6 330 mg/kg bw
Based on:
test mat.
95% CL:
4 514 - 8 902
Remarks on result:
other: calculated using density (chapter 4.4)
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
not determined

Applicant's summary and conclusion