Registration Dossier
Registration Dossier
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EC number: 203-960-0 | CAS number: 112-33-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication but only limited data is given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 969
Materials and methods
- Principles of method if other than guideline:
- Method: according to Smyth, Carpenter, Weil, Pozzani and Striegel: Range-Finding Toxicity Data: List VI, Amer. Ind. Hyg. Assoc. J. 23: 95 (1962) for details see any other information on materials and methods
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-[2-(3-aminopropoxy)ethoxy]ethanol
- EC Number:
- 203-960-0
- EC Name:
- 2-[2-(3-aminopropoxy)ethoxy]ethanol
- Cas Number:
- 112-33-4
- Molecular formula:
- C7H17NO3
- IUPAC Name:
- 2-[2-(3-aminopropoxy)ethoxy]ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 3-Aminopropoxy-2-ethoxy ethanol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped skin on the trunk
- Type of wrap if used: impervious plastic film
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data - Duration of exposure:
- 24 hours
- Doses:
- no data
- No. of animals per sex per dose:
- 4 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no - Statistics:
- Based upon mortalities during a 14 day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson (Thompson W.R.: Use of Moving Averages and Interpolation to estimate Median Effective Dose, Bacteriol. Rev. 11: 115, June 1947) using Tables of Weil (Weil C. S.: Tables for convenient calculation of Median-Effective Dose (LD50 or ED50) and Instructions in their Use, Biometrics 8: 249, Sept. 1952).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5.99 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 4.27 - 8.42
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 330 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 514 - 8 902
- Remarks on result:
- other: calculated using density (chapter 4.4)
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- not determined
Applicant's summary and conclusion
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