Registration Dossier
Registration Dossier
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EC number: 203-960-0 | CAS number: 112-33-4
Endpoint summary
Administrative data
Description of key information
skin: corrosive - rabbit (occlusive), TCAS.OTS0537491 (1990)
eye: corrosive - rabbit, Smyth et al., 1969
Key value for chemical safety assessment
Additional information
In a primary dermal irritation study (TSCA.OTS0537491 (1990)), 6 rabbits were dermally exposed to 0.5 mL of 3-Aminopropoxy-2-ethoxy ethanol for 3 minutes and 1 hour, after a previous skin irritancy test produced necrosis from 4 hours of occluded contact with 0.5 mL of the test substance. Animals were observed for 14 days. Irritation was scored by the method of Draize. In this study, 3-Aminopropoxy-2-ethoxy ethanol is corrosive to the skin when animals are exposed for 1 hour, since all animals developed necrosis.
In a second irritation study (Smyth et al. 1969), where only limited data is provided, 5 albino rabbits were dermally exposed to 0.01 mL of the test substance for 24 hours. Irritation was recorded in a 10-grade ordinal series. 3-Aminopropoxy-2-ethoxy ethanol was classified as grade 3 but did not cause necrosis. However, since a lower substance volume was used and no further details are given on effects on skin, severity of irritation cannot be directly assessed from this study but supports findings of the primary skin irritation study.
In a primary eye irritation study by Smyth et al. 1969, 3-Aminopropoxy-2-ethoxy ethanol was instilled into the conjunctival sac of albino rabbits for 24 hours without washing. Irritation was scored in a 10-grade ordinal series and based upon the degree of corneal necrosis that results from various volumes and concentrations of chemical.
In this study, 3-Aminopropoxy-2-ethoxy ethanol was corrosive to the eye.
Justification for classification or non-classification
Due to the studies on skin irritation, the eye irritation study and the pH value of 11.5, 3-Aminopropoxy-2-ethoxy ethanol is classified as corrosive (DSD: C; R34 – Causes Burns., CLP: skin corr. 1B; H314).
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