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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Endpoint:
toxicity to microorganisms
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Dose doc.no. : F60
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE);Schultz, T. W. et al Bull. Environ. Contam. Toxicol. 1989, 43(4), 564-569.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from DOSE Handbook
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-fluoroaniline
EC Number:
206-735-5
EC Name:
4-fluoroaniline
Cas Number:
371-40-4
Molecular formula:
C6H6FN
IUPAC Name:
4-fluoroaniline
Details on test material:
- Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Tetrahymena pyriformis

Study design

Test type:
not specified
Water media type:
not specified
Total exposure duration:
48 h

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
IC50
Effect conc.:
8 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
growth inhibition

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The IC50 value of 4-fluoroaniline to Tetrahymena pyriformis during a 48hr exposure is 8 mg/L
Executive summary:

The IC50 value of 4-fluoroaniline to Tetrahymena pyriformis during a 48hr exposure is 8 mg/L