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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro DNA damage and/or repair study
Remarks:
Type of genotoxicity: DNA damage and/or repair
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Dose No.: F60
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE);Zimmer, D. et al; Bacterial mutagenicity and mammalian cell DNA damage by several substituted anilines; Mutat. Res. 1980, 77(4), 317-326.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from DOSE Handbook
GLP compliance:
not specified
Type of assay:
DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
4-fluoroaniline
EC Number:
206-735-5
EC Name:
4-fluoroaniline
Cas Number:
371-40-4
Molecular formula:
C6H6FN
IUPAC Name:
4-fluoroaniline
Details on test material:
- Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid

Method

Species / strain
Species / strain / cell type:
Chinese hamster lung fibroblasts (V79)
Additional strain / cell type characteristics:
not specified
Metabolic activation:
not specified
Metabolic activation system:
none
Test concentrations with justification for top dose:
no data
Vehicle / solvent:
no data
Controls
Untreated negative controls:
not specified
Negative solvent / vehicle controls:
not specified
True negative controls:
not specified
Positive controls:
not specified
Positive control substance:
not specified

Results and discussion

Test results
Species / strain:
Chinese hamster lung fibroblasts (V79)
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

4-fluoroaniline gives negative results for DNA Damage test conducted on Chinese hamster lung fibroblast V79 cells.
Executive summary:

Several substituted alkyl- and haloanilines including 4-fluoroaniline were tested for their ability to damage the DNA of mammalian Chinese hamster lung fibroblast (V79) cells. These results were correlated with their reported carcinogenicity. On the basis of this study, it was found that 4-fluoroaniline gives negative results for DNA Damage test conducted on Chinese hamster lung fibroblast V79 cells.