Registration Dossier
Registration Dossier
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EC number: 219-847-4 | CAS number: 2550-26-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
A study on short-term toxicity to algae is not available for 4-phenylbutan-2-one. The endpoint was covered by read across from the structurally similar substance acetophenone. The 72-hour EC50 value for acetophenone determined in a 72-hour study with Pseudokirchneriella subcapitata under static conditions was 86.4 mg/L based on growth rate. The 72-hour NOEC value was 24.8 mg/L. By taking into account the molecular weights of acetophenone (120.15 g/mol) and 4-phenylbutan-2-one (148.2 g/mol) these values can be converted to an EC50 value of 106.6 mg/L and a NOEC value of 30.6 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 106.6 mg/L
- EC10 or NOEC for freshwater algae:
- 30.6 mg/L
Additional information
The short-term toxicity of the substance to freshwater alga is covered by read across from the structurally similar substance acetophenone (CAS number 98-86-2). A valid and reliable short-term toxicity study was conducted with Pseudokirchneriella subcapitata under static conditions over a period of 72 hours. The nominal test concentrations in the range from 12.5 to 200 mg/L were confirmed by analysis and effect levels were based on mean measured concentrations. The algal growth rate was not inhibited up to measured test concentrations of 24.8 mg/L over the test period of 72 hours. The EC50 value for inhibition of growth rate was calculated to be 86.4 mg/L. These values determined for acetophenone can be converted by using a factor of 1.2335 taking into account the molecular weights of acetophenone (120.15 g/mol) and 4-phenylbutan-2-one (148.2 mg/L).This results in an EC50 value of 106.6 mg/L and a NOEC value of 30.6 mg/L.
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