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EC number: 219-847-4 | CAS number: 2550-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The substance is not irritating to the skin or the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Key study
4-phenylbutan-2-one is considered to be not irritating to skin. The
result from a GLP study in rabbits conducted similar to OECD TG 404 was
considered reliable with restrictions and showed slight skin reactions
in 3 out of 4 animals that were reversible within 7 days. Only one
animal showed a very slight erythema (grade 0.5) until day 7 of the
study (Haynes 1988). Since this is a very slight erythema it might be
assumed that the reaction would be fully reversible within 14 days.
Supporting information
In the skin irritation study in rabbits from Bagley (1996) only slight,
reversible skin irritation is reported, supporting the
non-classification of 4 -phenylbutan-2-one.
Additionally, in two further in vitro studies with human skin it was concluded that the test substance is not corrosive skin in vitro (Fentem 1998, Kandarova 2006).
In a guideline-conform in vitro study with EpiSkin a relative absorbance of 46.0 % was reported and indicated a skin irritating potential of 4 -penylbutan-2-one (threshold for irritancy: ≤50%) (Heppenheimer 2012). However, the measured value was very close to the irritation threshold. Taking into account the negative results of the in vivo data, it is concluded that this in vitro test might be assumed to be false positive.
Eye irritation / corrosion
Key study
In the GLP and guideline-conform in vivo eye irritation study conducted in rabbits (Schreiter 1999) 4-phenylbutan-2-one is considered to be not irritating to the eye. All animals showed slight conjunctival effects at the examinations occurring 1 and 24 hours after treatment. However, all effects were transient and reversible within 48 hours after treatment. Based on these results it is concluded that the substance is non-irritating to the rabbit eye and no classification proposal is required.
Justification for selection of skin irritation / corrosion endpoint:
The most reliable GLP-study in vivo with principles closest to those of OECD TG 404 was chosen as key study.
Justification for selection of eye irritation endpoint:
The key study is a reliable GLP-study according to OECD TG 405.
Justification for classification or non-classification
- skin irritation/corrosion:
Based on the assessment of 4-phenylbutan-2-one, the results of two in vivo studies did not show any skin irritation potential of the tests substance. Accordingly, classification according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and CLP (Regulation (EC) No 1272/2008 of the European Parliament and of the Council) as implementation of UN-GHS in the EU is not required.
- eye irritation/corrosion:
Based on the assessment of 4-phenylbutan-2-one, the respective study did not show any corrosive or irritating potential to the eye. Accordingly, classification according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and CLP (Regulation (EC) No 1272/2008 of the European Parliament and of the Council) as implementation of UN GHS in the EU is not required.
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