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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Based on publications of the American Conference of Governmental Industrial Hygienists, 2001, and the National Library of Medicine, 2005.

Data source

Reference
Reference Type:
review article or handbook
Title:
Recommendation from the Scientific Committee on Occupational Exposure Limits for N-methylaniline
Author:
Scientific Committee on Occupational Exposure Limits
Year:
2010
Bibliographic source:
Scientific Committee on Occupational Exposure Limits (SCOEL), SCOEL/SUM/178, September 2010.

Materials and methods

Type of study / information:
Further based on:
1. NRC, National Research Council, 2000, Acute exposure guideline levels for selected airborne chemicals Vol. I, Nat. Acamedy Press, Washington DC.
2. Henschler D., 1992. Gesundheitsschaedliche Arbeitsstoffe, Toxicologisch-arbeitsmedizinische Begruendungen van MAK-Werten, Loseblattsammlung, 18.Deuatsche Forschungsgemeinschaft, VCH Verlag Weinheim.
3. Health & Safety Executive, 1997. Risk Assessment Document. EH72/8. Aniline. Suffolk, UK.
Endpoint addressed:
acute toxicity: oral
acute toxicity: inhalation
acute toxicity: dermal
Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-methylaniline
EC Number:
202-870-9
EC Name:
N-methylaniline
Cas Number:
100-61-8
Molecular formula:
C7H9N
IUPAC Name:
N-methylaniline

Method

Details on study design:
There are no data available regarding the acute toxicity of the test substance in humans but it is expected that acute test substance poisoning will resemble the acute toxicity of aniline, including induction of MetHb with cyanosis, weakness, dizziness and severe headache.
Exposure assessment:
estimated

Results and discussion

Results:
In most human individuals, the background MetHb level is between 1 and 2% and an increase up to 15% will be without significant signs or symptoms. Clinical cyanosis will develop at about 15-20% MetHb and more. Fatigue, anxiety, headache, weakness, dizziness, tachycardia, dyspnoea, and syncope will occur at 30-45% MetHb. Higher concentrations will cause a reduced level of consciousness and finally coma, heart failure and death at more than 60-70% MetHb.

Applicant's summary and conclusion

Conclusions:
Like aniline, test substance exposure can cause induction of MetHb in humans, which may lead to clinical signs of intoxication when MetHb concentrations increase to levels above 15% MetHb.