Registration Dossier
Registration Dossier
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EC number: 202-870-9 | CAS number: 100-61-8
Endpoint summary
Administrative data
Description of key information
Skin: not irritant
Eye: irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The value for skin irriation is initially based on a QSAR prediction and a study with rabbits. In addition, reference is made to observations during other dermal studies. The value for eye irritation is based on a recent GLP study according to the present guidelines. The value for respiratory irritation is derived from the available inhalation studies.
In all studies performed dermally, the test substance was not irritating to skin. In fact, dermally applied dosages causing severe effects in the bodies of test animals, including death, did not reveal significant irritation of the skin.
A GLP in vitro test with chicken eyes showed that the test substance caused slight corneal swelling, slight to moderate opacity, and slight fluorescein retention. The calculated Irritation Index was 65 out of a maximum possible score of 200.
The different inhalation studies in this dossier indicate that exposing of respiratory tissue to the test substance does not induce significant irritation, even at toxic concentrations.
Effects on eye irritation: irritating
Justification for classification or non-classification
Test substance is not irritant to the skin or respiratory tissue. According to CLP regulation 1272/2008 the test substance is considered to be Category 2: “Irritating to eyes”.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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