N-methylaniline

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

other: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

2002

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2002

Materials and methods

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

The experiments were aimed at comparing exposure of dogs via the oral route and inhalation to analyze the magnitude of error involved with route-to-route extrapolation.

GLP compliance:

yes

Test type:

other: Exposing of dogs to a sub-lethal concentration.

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Aniline

EC Number:

200-539-3

EC Name:

Aniline

Cas Number:

62-53-3

Molecular formula:

C6H7N

IUPAC Name:

aniline

Test animals

Species:

dog

Strain:

other: Beagle: Hsd Cpb: DOBE

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

head only

Vehicle:

air

Analytical verification of test atmosphere concentrations:

yes

Remarks:

Gas chromatography

Duration of exposure:

4 h

Remarks on duration:

A first group was exposed for 4 h continously whereas a second group was exposed 4 periods of 1 h, with a 10-minute break. Twelve days after inhalation, the dogs from the first group were exposed to aniline by oral route (gavage).

Concentrations:

Group I: 174 mg/m³; Group II: 155 mg/m³.

No. of animals per sex per dose:

4 dogs per group, not specified per sex.

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: Induction of 5% MetHb formation.

Effect level:

165 mg/m³ air (analytical)

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: Analytical results showed that Group I was exposed to 174 ± 8.3 mg/m³ and Group II to 155 ± 8.1 mg/m³, delivered doses are 15 and 13 mg/kg bw, respectively.

Applicant's summary and conclusion

Interpretation of results:

other: toxic

Remarks:

Through inhalation aniline appeared to be signficantly less toxic than by oral route. Criteria used for interpretation of results: expert judgment