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EC number: 234-919-5 | CAS number: 12040-43-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Rheinland-Pfalz, Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht
Test material
- Reference substance name:
- Silicic acid, aluminum magnesium sodium salt
- EC Number:
- 234-919-5
- EC Name:
- Silicic acid, aluminum magnesium sodium salt
- Cas Number:
- 12040-43-6
- Molecular formula:
- Na(0.017-1.739)Mg(0.008-0.823)Al(0.002-0.2473)SiO(2.018-3.837)
- IUPAC Name:
- aluminium(3+) magnesium(2+) sodium tris(oxosilanebis(olate))
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Name Silicic acid Aluminium Magnesium Sodium Salt
Batch no. code # 1107274003
Appearance white powder
Composition Silic acid Aluminium Magnesium Sodium Salt
CAS No. 12040-43-5
EINECS-No. 234-919-5
Purity > 99 %
Homogeneity homogeneous
Stability stable at room temperature
Solubility poorly soluble
Expiry date 01. Nov. 2018
Storage room temperature (20 ± 5 °C), dry
In vitro test system
- Test system:
- artificial membrane barrier model
- Source species:
- other: synthetic macromolecular bio-barrier
- Control samples:
- yes, concurrent negative control
Test animals
- Species:
- other: synthetic biobarrier
- Details on test animals or test system and environmental conditions:
- The Corrositex® test is an in vitro procedure by which the assessment of corrosivity is not carried out in live animals.
The Corrositex® test refers to the penetration of the membrane barrier which is measured by a change in the colour of a pH indicator dye.
Test system
- Controls:
- yes, concurrent positive control
- Duration of treatment / exposure:
- 60 min
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- negative control
- Value:
- > 60
- Negative controls validity:
- valid
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- positive control
- Value:
- ca. 12
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- test item
- Value:
- > 60
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
The controls showed the following results: The negative control showed no break-through within the observation time of 60 min.
The positive control showed clear corrosive effects after 12 minutes and is consequently classified as a corrosive substance belonging to UN Packing Group II.
Therefore the test item (substance category 2 according to the categorisation) is classified as a non-corrosive substance.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Silicic acid Aluminium Magnesium Sodium Salt is considered as not corrosive in the Corrositex® - Test.
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