Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 242-670-9 | CAS number: 18917-91-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No data on short term toxicity to aquatic algae are available for the substance Aluminium trilactate. Thus, a read-across to the moieties of Aluminium trilactate - Lactic acid and Aluminium is used for hazard assessment. This read-across approach is adequate as the salt Aluminium trilactate will dissociate into Lactic acid and Aluminium ions in aqueous solutions.
One study in Selenastrum capricornutum is available for Lactic acid. For Aluminium chloride one study in Chlorella pyrenoidosa is available: The 72/96 h ErC50 for Lactic acid was 3500 mg/L (nominal). The EC50 (based on growth rate) for Al was 158 µg Al/L (as dissolved Al).
The most critical EC50 in aquatic algae was 158 µg Al/L or recalculated to Aluminium trilactate 1.72 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 1.72 mg/L
Additional information
No data on short term toxicity to aquatic algae are available for the substance Aluminium trilactate. Thus, a read-across to the moieties of Aluminium trilactate - Lactic acid and Aluminium is used for hazard assessment. This read-across approach is adequate as the salt Aluminium trilactate will dissociate into Lactic acid and Aluminium ions in aqueous solutions.
One study in Selenastrum capricornutum is available for Lactic acid. For Aluminium chloride one study in Chlorella pyrenoidosa is available.
The toxicity of Lactic acid to Selenastrum capricornutum was investigated in a study conducted according to OECD Guideline (1984) or EPA Guideline EG-8. The test duration of the static test was 72 or 96 h (not specified in respect to Lactic acid). The test substance concentrations were enzymatically determined. The 72/96 h EbC50, ErC50 and NOEC were determined to be >2800, 3500, and 1900 mg/L (nominal), respectively.
In a 96 hour acute toxicity study, the cultures of Chlorella pyrenoidosa were exposed to Aluminium chloride at nominal concentrations of 0, 25, 50, 100, 150 µg/L under static conditions at pH values from 4.8 to 6.0.
The EC30 was determined by the authors to be 70 nmol/L (at pH 6) and 1.8 µmol/L at pH 5 (measured concentrations). The EC10 and EC50 (at pH 5) were determined by linear regression by the submitter based on nominal concentrations, available in the article. These values are 95 and 158 µg Al/L (as dissolved Al), respectively.
Toxicity of Aluminium to aquatic algae has also been reviewed by Environment Canada (2010), WHO IPCS EHC (1997) and US ATSDR (2008). These reviews and the literature cited therein have also been taken into account for hazard assessment.
The most critical EC50 in aquatic algae was 158 µg Al/L or recalculated to Aluminium trilactate 1.72 mg/L.
References:
Environment Canada (2010)Environment Canada Priority Substance List Assessment Report, Follow-up to the State of Science Report, 2000 Aluminium Salts (Final Content), available via internet: http://www.ec.gc.ca/lcpe-cepa/default.asp?lang=En&n=491F0099-1 and http://www.ec.gc.ca/lcpe-cepa/documents/substances/sa-as/final/al_salts-eng.pdf
US ATSDR (United States Agency for Toxic Substances and Disease Registry)(2008) Toxicological profile for Aluminium, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, Public Health Service, Agency for Toxic Substances and Disease Registry, available via internet: http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=191&tid=34
WHO IPCS EHC (World Health Organisation International Programme on Chemical Safety Environmental Health Criteria)(1997) Aluminium (Environmental health criteria; 194), IPCS, World Health Organization, Geneva, available via internet: http://www.inchem.org/documents/ehc/ehc/ehc194.htm
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
