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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report date:
2011

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 428 (Skin Absorption: In Vitro Method)
Qualifier:
according to guideline
Guideline:
other: OECD Guidance Document No. 28
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Aluminium trilactate
EC Number:
242-670-9
EC Name:
Aluminium trilactate
Cas Number:
18917-91-4
Molecular formula:
C9H15AlO9
IUPAC Name:
Aluminium trilactate
Details on test material:
- Name of test material (as cited in study report): Aluminium Lactate
- Analytical purity: Aluminium 2.1 g/100g
- Lot/batch No.: 2426/10

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: The solution is prepared in tap water by the producer. The test substance was used as given by the producer; no additional test-substance preparation was carried out.
Duration of exposure:
8 h (Times of sampling of receptor fluid: 0; 1; 2; 4; 6; 8; 10 and 24 hours after application)
Doses:
nominal dose: 210.74 µg/cm²

Results and discussion

Absorption in different matrices:
0.06% of Aluminium Lactate (expressed as aluminium) was absorbed through human skin over a treatment period of 8 hours under the test conditions used.

Any other information on results incl. tables

Although the mean total recoveries are below the quality criteria put forward in the test guidelines, the study is assessed to be valid in general. The main contents of Aluminium Lactate (measured as aluminium contents) were detected in the washing solution after eight hours (85.69%). Allmost no test substance was found in receptor fluid and receptor chamber washing fluid. In conclusion, 0.06% of Aluminium Lactate (expressed as aluminium) was absorbed through human skin over a treatment period of 8 hours under the test conditions used.

Applicant's summary and conclusion