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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

For the most sensitive species, Pimephales promelas, NOECs from three early life stage tests are available (Cairns and Nebeker, 1982; Lemke et al., 
1983, test 1+2, exposure period 32-35 days) that are in the same order of magnitude. Therefore, the geometric mean of these 3 NOECs is calculated resulting in a value of 8.9 mg/l. The studies were conducted according to accepted scientific principles and were assessed as "reliable with
restrictions".

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
8.9 mg/L

Additional information

A flow-through test using Pimephales promelas embryos (maximum 48 hours old) was conducted by Cairns and Nebeker (1982). Observing the fork length, a NOEC of 19 mg/l and a LOEC of 30 mg/l were obtained, while the fish weight was affected by 19 mg/l and higher but not by 11 mg/l. Based on fish weight as the most sensitive endpoint the NOEC is determined as 11 mg/l. Similar results were obtained in 2 flow-through tests using the same species (Lemke et al., 1983). After 32 days of exposure, NOECs for the endpoint fish weight of 4.2 (2nd test) and 15.6 mg/l (1st test) were obtained. The authors explained the deviation of the results with differences in the feeding regime.