Registration Dossier

Administrative data

Endpoint:
biotransformation and kinetics
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Preparation of aroma compounds by microbial transformation of isophorone with Aspergillus niger
Author:
Mikami Y, Fukunaga Y, Arita M, Obi Y and Kisaki T
Year:
1981
Bibliographic source:
Agric. Biol. Chem. 45, 791-793

Materials and methods

Type of medium:
other: fungi

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Transformation products:
yes
Identity of transformation productsopen allclose all
No.:
#1
Reference
Reference substance name:
Unnamed
IUPAC name:
3,5,5-trimethyl-2-cyclohexene-1,4-dione
Identity:
3,5,5-trimethyl-2-cyclohexene-1,4-dione
No.:
#2
Reference
Reference substance name:
Unnamed
IUPAC name:
3,5,5-trimethylcyclohexane-1,4-dione
Identity:
3,5,5-trimethylcyclohexane-1,4-dione
No.:
#3
Reference
Reference substance name:
Unnamed
IUPAC name:
4-hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one
Identity:
4-hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one
No.:
#4
Reference
Reference substance name:
Unnamed
IUPAC name:
3-hydroxymethyl-5,5-dimethyl-2-cyclohexen-1-one
Identity:
3-hydroxymethyl-5,5-dimethyl-2-cyclohexen-1-one

Any other information on results incl. tables

RS-Freetext:
Microbial transformation yielded the following metabolites: 
3,5,5-trimethyl-2-cyclohexene-1,4-dione,
3,5,5-trimethylcyclohexane-1,4-dione,
4-hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one, and
3-hydroxymethyl-5,5-dimethyl-2-cyclohexen-1-one.

Applicant's summary and conclusion