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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Several literature studies on the acute aquatic toxicity of Propan-1 -ol is available. The following endpoints represent a selection of the most valid and sensitive studies.

Results on acute aquatic toxicity are available for:


  • LC50 (96 hours) Pimephales promelas 4555 mg/l, measured, freshwater (Brooke et al. 1984)
  • LC50 (48h) Oncorhynchus mykiss 3200 mg/l, nominal, freshwater (Slooff et al. 1983)
  • LC50 (96h) Alburnus alburnus 3800 mg/l, nominal, brackish water (Bengtsson et al. 1984)
  • read-across to Propan-2 -ol (CAS: 67 -63 -0): NOEC (14d) Oryzias latipes 1000 mg/l, measured, freshwater (Japanese National Institute of Technology and Evaluation (2007): Chemical Risk Information Platform, Comprehensive data for CAS 67-63-0. 03 May 2007)


  • EC50 (48 hours) Daphnia magna 3644 mg/l, nominal, freshwater (Kuehn et al. 1989)
  • EC50 (48 hours) Gammarus pulex 1000 mg/l, nominal, freshwater (Slooff et al. 1983)
  • EC50 (24h) Daphnia magna 4415 mg/l, nominal, freshwater (Bringmann and Kuehn 1982)


  • EC50 (48 hours) Pseudokirchneriella subcapitata 6370 mg/l, nominal, freshwater (Hsieh et al. 2006)
  • NOEC (48 hours) Chlorella pyrenoidosa, 1150 mg/l, nominal, freshwater (Slooff et al. 1983)
  • EC03 (192 hours) Scenedesmus quadricauda 3100 mg/l, nominal, freshwater (Bringmann and Kuehn 1980)

Inhibition of oxygen consumption in activated sludge IC50 (3h) was not observed up to concentrations of 1000 mg/l Propan-1 -ol (Klecka and Landi 1985). These results indicate that Propan-1 -ol is acute not harmful to aquatic organisms and that an inhibition of the degradation activity of activated sludge is unlikely to occur in wastewater treatment plants.

There are no data on the chronic toxicity of Propan-1 -ol to fish. A NOEC 21-d of 68.3 mg/L for Daphnia magna has been estimated with the OECD QSAR Toolbox v.4.2. In addition, for the structurally related 2 -Propanol, a test performed according to OECD guideline 211 is available, revealing no effects on reproduction (NOEC) of Daphnia magna at test substance concentrations > 100 mg/l and by thereby underlining the little hazard potential of Propan-1 -ol as observed in acute studies.