Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-746-9 | CAS number: 71-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- secondary source
- Title:
- EU Risk Assessment Report, CAS No. 71-23-8: Propan-1-ol, Vol. 82
- Author:
- not applicable
- Year:
- 2 008
- Bibliographic source:
- ECB
Materials and methods
- Endpoint addressed:
- basic toxicokinetics
- dermal absorption
- Principles of method if other than guideline:
- Summarized overview of available human data as given in the EU RAR 2008.
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-1-ol
Constituent 1
Results and discussion
- Results:
- see below.
Any other information on results incl. tables
DERMAL
The penetration through human skin was qualitatively demonstrated in volunteers: Rubbing hands and underarms for five minutes with propan-1-ol containing antiseptics (estimated amount propan-1-ol applied: 9-15 g) resulted in peak levels in blood taken from a foot vein from 0.2 to 0.4 mg/l (Peschel et al., 1992).
Oral
In studies with human volunteers ingesting orange juice containing alcohols (5 mg/kgbw propan-1-ol and 0.8 g /kgbwethanol) blood levels of propan-1-ol peaked 15 minutes after the ending of the drinking period (30 or 60 minutes), indicating a rapid absorption from the GI tract (Bilzer et al., 1990). Schmutte et al. (1988) could not detect propan-1-ol in the blood of 9 from 10 volunteers
within 15 min after finishing drinking (16 whole blood samples/person, gas-liquid chromatography) of propan-1-ol doses in water of up to 12.5 mg/kg, probably due to a significant 'first pass' effect.
For evaluating the concentration of propan-1-ol in saliva, drinking test was performed with 10 test persons. The alcoholic drink was wine. During thetest ,the test persons each received 1 g ethanol (given equivalent as wine) /kg bw for 1 hour and the quantities of other alcohols, naturally contained in the beverage. Propan-1-ol concentrations in saliva were found to be up to 4 to 5 times higher than those in blood after the consumption of wine (Hein et al., 1989).
OTHER
Wehner and Schieffer (1989) administered doses of 25, 50, 100, 200, and 300 mg propan-1-ol intravenously to one male (bw69 kg) and one female (bw 72 kg) volunteer. Based on a three compartment open system model and a non-linear elimination process controlled by Michaelis-Menten kinetics the authors calculated a Michaelis-Menten constant (Km) of approximately 10 mg/l and a maximal initial velocity of metabolism (Vmax) of 2.5 mg/l/min.
Tissue-gas partition coefficients were determined for propan-1-ol using head-space methods. Human tissues were obtained by autopsy. Blood and several representative tissues were examined: blood (866 + 55), muscle (651 + 28), kidney (713 + 33), lung (698 + 37), brain gray (749 + 23) ,fat (287 + 8). For liver a tissue-gas partition-coefficient of 564 was calculated. The solvent tend to be more soluble in plasma (969 + 60) than in erythrocytes (799 + 99). It has been shown that solubility of propan-1-ol not increases with lipid content in blood and tissues (Fiserova-Bergerova and Diaz, 1986).
Permeation rates (flux) of pure liquid propanol and aqueous solutions of propan-1-ol,
respectively, were determined in a diffusion cell using abdominal skin from human adults:
through epidermis - 96 μg/cm²/h vs. 6 μg/cm²/h (Scheuplein and Blank, 1973).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.