Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-746-9 | CAS number: 71-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Remarks:
- other: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Relative Acute Neurotoxicity of Solvents : Isoeffective Air Concentrations of 48 Compounds Evaluated in Rats and Mice
- Author:
- Frantik E., Hornychovà M., Horváth M.
- Year:
- 1 994
- Bibliographic source:
- Environ. Res. 66, 173-185
Materials and methods
- Principles of method if other than guideline:
- Effect-air concentration regressions of 48 common solvents (aromatic, aliphatic, and chlorinated hydrocarbons, alcohols, ketones, acetates) were determined for 4-hr inhalation exposures in male rats. Inhibition of propagation and E maintenance of the electrically evoked seizure discharge was used as a criterion of the acute neurotropic effect. The isoeffective concentrations in air were estimated by interpolation on the level of one-third of the maximum effect (ECC).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-1-ol
Constituent 1
- Specific details on test material used for the study:
- The test substance was described as analytically pure.
Test animals
- Species:
- rat
- Strain:
- other: Wistar albino SPF
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: 0.5-1yr
- Housing: 1/cage
- Diet: pelleted DOS2b with a supraoptimal concentrations of vitamins (maximum of 12g/d)
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- other: inhalation: vapour (whole body)
- Vehicle:
- other: air
- Details on exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Whole body exposures were carried out in 80-liter glass chambers operated under dynamic conditions. The experimental subjects (1 rat) were placed into small plastic boxes ventilated through diffusion tubes permitting almost instant stabilization of the air concentration in the respiration zone. The exposure started after an approx 30 min habituation and lasted 4h.
TEST ATMOSPHERE
- Brief description of analytical method used: GC
- Samples taken from breathing zone: yes - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Methode: gas chromatography
- Duration of treatment / exposure:
- 4h
- Frequency of treatment:
- intervals between exposures being at least 3 weeks .
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
nominal conc.
- No. of animals per sex per dose:
- Test group: 4 /dose
Control: 4 - Control animals:
- yes, sham-exposed
Examinations
- Neurobehavioural examinations performed and frequency:
- Each compound was tested in at least two independent experiments on two samples of animals exposure box. A short electrical impulse (0 .2 sec, 50 Hz, 180 V in rats) was through ear electrodes. The duration of tonic extentions of hind limbs in rats was measured. All animals were given three control tests at weekly intervals before the first exposure. Measuring of the biological effect always started less than 1 min after removal. The median of individual control values was subtracted from the values observed after exposure. Group means of differences were corrected for the difference in the simultaneously tested control group and converted to relative values i.e percentages of the arbitrary maximum values, which for rats was 8 sec
- Statistics:
- All data (including zero concentration group) were processed using linear reregression analysis. If the component for nonlinearity was significant, then the highest and/or the zero concentration groups were omitted, but the number of exposure levels was not allowed to drop below three. The effect in the lower lower third of the linear part of the dose-response function was chosen as the critical level, i .e ., shortening of the tonic extension of hindlimbs by 3 sec in rats. Isoeffective concentrations, corresponding to the critical level of effect (ECC), interpolated on all regression lines and 90% confidence intervals computed. The lowest effective concentration (EC10) was interpolated-or extrapolated in cases when the zero concentration group was omitted-on a level of the maximum possible effect
Results and discussion
Results of examinations
- Details on results:
- - The saturated vapour concentration at 37°C was derived from the values given in the publication to be 70000 ppm (178.8 mg/ml)
Effect levels
- Dose descriptor:
- other: Isoeffective concentration (EEC)
- Effect level:
- 32.2 mg/L air
- Sex:
- male
- Basis for effect level:
- other: 95% confidence limits (26.6 - 37.8). Concentration effecting a 30% depression in the duration of tonic extension of hindlimb of the rat
- Remarks on result:
- other: Generation not applicable
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
