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Long-term toxicity to aquatic invertebrates

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Description of key information

No experimental data for 1-propanol. A QSAR-study conducted with accepted calculation method (OECD QSAR Toolbox v4.2)revealed no reproductive effects at concentration of 68 mg/L. 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
68.3 mg/L

Additional information

The hazard assessment of Propan-1 -ol reveals neither a need to classify the substance as dangerous to the environment, nor PBT or vPvB properties. Concerning long-term toxicity to aquatic invertebrates there are no further indications that the substance may be hazardous to the environment. A QSAR-study conducted with the OECD QSAR Toolbox v4.2 (trend analysis within category members) reveals no reproduction effects to Daphnia magna at a concentration of 68.3 mg/L. The very low chronic toxicity of propan-1 -ol to aquatic invertebrates is supported by the result of a study on the chonic toxicity of the structurally related substance 2 -Propanol (CAS: 67-63-0) to Daphnia magna (performed according to OECD guideline 211 under GLP conditions), where no reproductive effects were observed at concentrations up to 100 mg/l (NOEC > 100 mg/l). In addition, it is very well known that aliphatic alcohols act by non-specific mode of action (narcotic effect). Bengtsson et al. (Chemosphere, Vol. 13, No. 5/6, pp 613 – 622, 1984) have demonstrated in a study with a series of aliphatic alcohols (C1 – C13) that their toxicity is highly correlated to the number of carbon atoms and that the differences in toxicity for the individual compounds in the series can be explained in terms of differences in lipophilicity. Taking into account that propan-1-ol and propan-2-ol are both of very low lipophilicity, the result of the long-term study with daphnids on propan-2-ol can be use to support the low chronic toxicity of propan-1-ol towards aquatic invertebrates.