Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-480-0 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented study performed according to internationally accepted method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Study was performed to evaluate the potential skin irritant effects of copper slag based on EU B4 method - Acute toxicity - Skin irritation. The tested substance was applied in a single dose on the skin of laboratory animals, using the untreated skin areas as control.
- GLP compliance:
- no
- Remarks:
- other quality assurance
Test material
- Reference substance name:
- Iron silicate, copper smelting and refining
- EC Number:
- 701-480-0
- Cas Number:
- 67711-92-6
- IUPAC Name:
- Iron silicate, copper smelting and refining
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Rabbit healthy adult male albino
The diet was standard for these animals. Animal house temperature was maintained at 20 + / - 2c, the relative humidity was between 30 -70% and photoperiod was 12/12 hours light / dark
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- single dose
- Observation period:
- 24, 48 and 72 hours
- Number of animals:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No formation of erythema observed
No formation of edema observed
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This is a good quality study. The sample is not skin irritant
- Executive summary:
Study was performed to evaluate the potential skin irritant effects of copper slag based on EU B4 method - Acute toxicity - Skin irritation.
Based on the results, copper slag is not skin irritant. The absence of irritation effects furthermore excludes the possibility of corrosion, defined as a strategic destruction of tissues throughout the skin thickness
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
